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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0075-v2Release info

This page is a past version (v2). The latest version is v3.
Latest version (v3)

Research title

Search for susceptibility genes to hepatitis virus B-related diseases

Research overview

Aims
Search for susceptibility genes to hepatitis virus B (HBV)-related diseases
Methods
SNP-based genome-wide association study (GWAS)
Participants/materials
1. 181 HBV carriers and 184 controls
2. 181 HBV carriers and 185 spontaneously HBV-resolved individuals
3. 185 spontaneously HBV-resolved individuals and 184 controls
4. 473 HBV-positive hepatocellular carcinoma (HCC) patients and 516 HBV carriers including chronic hepatitis and asymptomatic carriers
URL
N/A

Datasets

The list is the one this version published; each dataset's content is shown as it is now.

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
NHA000055GWAS for 181 HBV carriers and 184 controls
  • Genotyping by array
Unrestricted-access2017-09-25
NHA000056GWAS for 181 HBV carriers and 185 spontaneously HBV-resolved individuals
  • Genotyping by array
Unrestricted-access2017-09-25
NHA000054GWAS for 185 spontaneously HBV-resolved individuals and 184 controls
  • Genotyping by array
Unrestricted-access2017-09-25
NHA000079GWAS for 473 HBV-positive HCC patients and 516 HBV carriers
  • Genotyping by array
Unrestricted-access2019-02-19

Data provider

Principal investigator
Masashi Mizokami
Affiliation
Department of Liver Diseases, The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine

Research projects

NameURL
Genome Medical Science Project
N/A

Grants

NameTitleProject number
Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan
Database construction and therapeutic applications including host genetic factors related with viral hepatitis
  • H22-kanen-005
Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan
Development of diagnostics and treatment for hepatitis B related diseases based on genome-wide genetic analysis
  • H23-kanen-005
Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan
Identification of genes associated with hepatitis B virus-related diseases by genome-wide analyses
  • H26-kanen-004
Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan
Identification of HLA allelss and immume-related genes associated with chronic hepatitis B and viral clearance
  • H25-kanen-012
KAKENHI Grant-in-Aid for Young Scientists (B)
Identification of host genetic factors related with chronic hepatitis B
  • 25870178
Miyakawa Memorial Research Foundation
Identification of host genetic factors related with chronic hepatitis B and HBV-related cancer
N/A

Related publications

TitleDOIDataset ID
Genome-Wide Association Study Confirming Association of HLA-DP with Protection against Chronic Hepatitis B and Viral Clearance in Japanese and Korean
https://doi.org/10.1371/journal.pone.0039175 (opens in a new tab)
Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma
https://doi.org/10.1038/s41598-018-26217-7 (opens in a new tab)