Research ID
hum0075-v3Release info
Latest
Research title
Search for susceptibility genes to hepatitis virus B-related diseases
Research overview
- Aims
- Search for susceptibility genes to hepatitis virus B (HBV)-related diseases
- Methods
- SNP-based genome-wide association study (GWAS)
- Participants/materials
- 1. 181 HBV carriers and 184 controls
2. 181 HBV carriers and 185 spontaneously HBV-resolved individuals
3. 185 spontaneously HBV-resolved individuals and 184 controls
4. 473 HBV-positive hepatocellular carcinoma (HCC) patients and 516 HBV carriers including chronic hepatitis and asymptomatic carriers
5. 329 patients with chronic HBV infection who were recruited at Chulalongkorn University in Bangkok, Thailand, and 318 healthy control individuals who were blood donors at the National Blood Center, The Thai Red Cross Society, in Bangkok, Thailand - URL
- N/A
Datasets
| Cart | Dataset ID | Type of data | Analysis method | Access criteria | Date published |
|---|---|---|---|---|---|
| NHA000055 | GWAS for 181 HBV carriers and 184 controls |
| Unrestricted-access | 2017-09-25 | |
| NHA000056 | GWAS for 181 HBV carriers and 185 spontaneously HBV-resolved individuals |
| Unrestricted-access | 2017-09-25 | |
| NHA000054 | GWAS for 185 spontaneously HBV-resolved individuals and 184 controls |
| Unrestricted-access | 2017-09-25 | |
| NHA000079 | GWAS for 473 HBV-positive HCC patients and 516 HBV carriers |
| Unrestricted-access | 2019-02-19 | |
| NHA000170 | GWAS for 329 patients with chronic HBV infection and 318 healthy controls |
| Unrestricted-access | 2022-05-27 |
Data provider
- Principal investigator
- Masashi Mizokami
- Affiliation
- Department of Liver Diseases, The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine
Research projects
| Name | URL |
|---|---|
Genome Medical Science Project | N/A |
Grants
| Name | Title | Project number |
|---|---|---|
Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan | Database construction and therapeutic applications including host genetic factors related with viral hepatitis |
|
Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan | Development of diagnostics and treatment for hepatitis B related diseases based on genome-wide genetic analysis |
|
Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan | Identification of genes associated with hepatitis B virus-related diseases by genome-wide analyses |
|
Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan | Identification of HLA allelss and immume-related genes associated with chronic hepatitis B and viral clearance |
|
KAKENHI Grant-in-Aid for Young Scientists (B) | Identification of host genetic factors related with chronic hepatitis B |
|
Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science Program for Basic and Clinical Research on Hepatitis, Japan Agency for Medical Research and Development (AMED) | Study for clinical sequening based on genome analysis of host and viral factors |
|
Miyakawa Memorial Research Foundation | Identification of host genetic factors related with chronic hepatitis B and HBV-related cancer | N/A |
Related publications
| Title | DOI | Dataset ID |
|---|---|---|
Genome-Wide Association Study Confirming Association of HLA-DP with Protection against Chronic Hepatitis B and Viral Clearance in Japanese and Korean | ||
Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma | ||
Genome-wide association study for chronic hepatitis B infection in the Thai population |