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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0032-v1Release info

Latest

Research title

Standard epigenome mapping in human epithelial cells of the digestive and urogenital organs (HPC series)

Research overview

Aims
The aim of this study is to participate in International Human Epigenome Consortium (http://ihec-epigenomes.org/), through disclosure of quality reference epigenome profiles in normal and diseased cells obtained from multiple Japanese people.
Methods
ChIP-Seq, RNA-seq and PBAT-seq analysis about normal and diseased human hepatocytes purified from partial hepatectomy specimens.
Participants/materials
Normal and diseased human hepatocytes purified from partial hepatectomy specimens (normal human hepatocytes: 6, hepatitis B virus (HBV)-positive human hepatocyte 1 and hepatitis C virus (HCV)-positive human hepatocyte 1.
URL

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000026NGS (PBAT-seq)
  • PBAT-seq
Controlled-access (Type I)2020-09-28
JGAD000027NGS (ChIP-seq)
  • ChIP-seq
Controlled-access (Type I)2020-09-28
JGAD000028NGS (RNA-seq)
  • RNA-seq
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Yae Kanai
Affiliation
Department of Pathology, Keio University School of Medicine

Research projects

NameURL
AMED-CREST International Human Epigenome Consortium (IHEC) Team Kanai

Grants

NameTitleProject number
Core Research and Evolutional Science and Technology, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-CREST)
Development of Fundamental Technologies for Diagnosis and Therapy Based upon Epigenome Analysis
N/A

Related publications

TitleDOIDataset ID
Amplification-free whole-genome bisulfite sequencing by post-bisulfite adaptor tagging.
https://doi.org/10.1093/nar/gks454 (opens in a new tab)
Multilayer-omics analyses of human cancers: exploration of biomarkers and drug targets based on the activities of the International Human Epigenome Consortium.
https://doi.org/10.3389/fgene.2014.00024 (opens in a new tab)
N/A

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Guillaume BourqueMcGill University & Genome Quebec Innovation Center, McGill UniversityQuebec, CanadaEpigenome Meta-Analysis Project (epiMAP)2018-06-07 – 2021-03-19
Martin HirstBC Cancer, part of the Provincial Health Services AuthorityBritish Columbia, CanadaEpigenomic analysis of human samples2018-08-06 – 2022-09-05
Quan LongFaculty of Medicine, Department of Biochemistry & Molecular Biology, University of CalgaryAlberta, CanadaCharacterizing intrapatient methylome evolution through epihaplotype reconstruction and applied deep learning models.2019-01-21 – 2023-09-21
Quan LongFaculty of Medicine, Department of Biochemistry & Molecular Biology, University of CalgaryAlberta, CanadaCharacterizing intrapatient methylome evolution through epihaplotype reconstruction and applied deep learning models.2019-05-13 – 2021-03-19
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31