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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0028-v2Release info

Latest

Research title

Biobank Japan Project

Research overview

Aims
Construction of the HLA imputation reference panel of the Japanese healthy controls
Methods
SNPs in the HLA region were genotyped by Illumina BeadChips (HumanOmniExpress BeadChip, HumanExome BeadChip, Immunochip, HumanHap550v3 Genotyping BeadChip) and HLA alleles (HLA-A/C/B/DRB1/DQA1/DQB1/DPA1/DPB1) were determined by WAKFlow HLA typing kit or sequence based method.
Participants/materials
908 Japanese healthy controls
URL

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000018HLA alleles and SNPs
in HLA region (7 loci)
  • Targeted DNA sequencing
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Michiaki Kubo
Affiliation
RIKEN Center for Integrative Medical Science

Research projects

NameURL
Laboratory for Genotyping Development and Laboratory for Statistical Analysis

Grants

NameTitleProject number
Ministry of Education, Culture, Sports, Science and Technology in Japan
Tailor-made Medical Treatment Program (the 3rd phase)
N/A

Related publications

TitleDOIDataset ID
Construction of a population-specific HLA imputation reference panel and its application to Graves' disease risk in Japanese
https://doi.org/10.1038/ng.3310 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Takashi KohnoDivision of Genome Biology, National Cancer CenterJapanSearch for genes involved in susceptibility to lung cancer2016-02-15 – 2028-12-31
Hajime YoshifujiDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of MedicineJapanTo impute HLA alleles of patients with autoimmune diseases and helathy people to fine-map the HLA region to clarify the associations between the HLA locus and diseases susceptibility or diseases' phenotypes2016-06-06 – 2023-08-02
Emiko NoguchiDepartment of Medical Genetics, Faculty of Medicine, University of TsukubaJapanIdentification of genes related to allergy against hydrozyed wheat protein.2016-08-25 – 2022-03-07
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of MedicineJapanDevelopment of statistical genetic analysis methods using the whole-genome data from B cell lines of Japanese individuals2018-09-20 – 2029-03-31
Eisei NOIRIUniversity Hospital, The University of TokyoJapanGenetic Analysis for Occurrence or Worsening Factors toward End Stage Kidney Disease in Chronic Kidey Diseases2018-12-18 – 2019-09-20
Emiko NoguchiFaculty of Medicine, University of TsukubaJapanGenome analysis for Wheat Dependent Exercise-Induced Anaphylaxis and Search for Appropriate Wheat Species2020-02-28 – 2023-04-07
Emiko NoguchiFaculty of Medicine, University of TsukubaJapanSearch for genetic factors associated with allergic diseases2020-02-28 – 2023-04-06
Emiko NoguchiFaculty of Medicine, University of TsukubaJapanIdentification of factors associated with allergic diseases and their associated phenotypes2020-02-28 – 2029-03-31
Emiko NoguchiFaculty of Medicine, University of TsukubaJapanComprehensive analysis of the pathogenesis of chronic eosinophilic inflammatory diseases2021-05-07 – 2030-03-31
Yohei KirinoDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of MedicineJapanGenetic analysis for an immune-related adverse event caused by immune checkpoint inhibitors2020-06-10 – 2023-03-15
Taisei MushirodaRIKEN Center for Integrative Medical SciencesJapanSNP analysis of wheat allergy2021-03-26 – 2028-03-31
Hajime YoshifujiDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of MedicineJapanTo impute HLA alleles of patients with autoimmune diseases and healthy people to fine-map the HLA region to clarify the associations between the HLA locus and diseases susceptibility or diseases' phenotypes2021-07-26 – 2023-08-02
Emiko NoguchiDepartment of Medical Genetics, Faculty of Medicine, University of TsukubaJapanIdentification of the pathogenic factors for food allergy2021-12-08 – 2029-03-31
Hajime YoshifujiDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of MedicineJapanTo impute HLA alleles of patients with autoimmune diseases and helathy people to fine-map the HLA region to clarify the associations between the HLA locus and diseases susceptibility or diseases' phenotypes2022-06-23 – 2025-06-16
Emiko NoguchiDepartment of Medical Genetics, Faculty of Medicine, University of TsukubaJapanResearch on genetic predisposition to inflammatory lung disease2022-09-21 – 2027-03-31
Keiko YamazakiDepartment of Public Health, Chiba University Graduate School of MedicineJapanPrediction of effectiveness to molecular target drugs in Japanese patients with inflammatory bowel disease2022-11-15 – 2030-03-31
Koya FukunagaMedical safety science, National institute of health sciencesJapanResearch on the diagnosis, treatment, and biomarkers for severe cutaneous adverse reactions2023-02-10 – 2026-03-02
Koya FukunagaMedical safety science, National institute of health sciencesJapanResearch on the biomarkers associated with drug-induced interstitial pneumonia2023-02-10 – 2026-03-02
Koya FukunagaMedical safety science, National institute of health sciencesJapanResearch on the biomarkers associated with drug-induced liver injury 2023-02-10 – 2024-04-02
Koya FukunagaMedical safety science, National institute of health sciencesJapanResearch on the biomarkers associated with drug-induced myopathy 2023-02-10 – 2026-03-02
Yuta KochiDepartment of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental UniversityJapanGenetic study of complex diseases through comprehensive analysis of functional genetic variations2023-04-12 – 2028-03-31
Emiko NoguchiDepartment of Medical Genetics, Faculty of Medicine, University of TsukubaJapanGenome wide association study for WDEIA and exploration of wheat products2024-05-09 – 2028-03-31
Takeshi KanekoPulmonary Department, Yokohama Ciyu UniversityJapanClarification of genetic factors involved in COVID-192024-06-19 – 2025-04-04
Kouya ShiraishiDepartment of Clinical Genomics, National Cancer Center Research InstituteJapanSearch for genes involved in susceptibility to lung cancer2024-06-24 – 2025-12-15
Taisei MushirodaLaboratory for Pharmacogenomics, RIKEN Center for Integrative Medical SciencesJapanSearch of genomic biomarkers associated with drug-induced eruptions2024-08-01 – 2028-03-31
Kazuyoshi IshigakiLaboratory for Human Immunogenetics, RIKEN Center for Integrative Medical SciencesJapanCross-disease analysis of T cell receptors and B cell receptors/Identification and functional analysis of risk polymorphisms in autoimmune diseases2024-12-23 – 2028-03-31
Emiko NoguchiDepartment of Medical Genetics, Faculty of Medicine, University of TsukubaJapan Genetic and protein analysis of allergic diseases and allergic rhinitis.2024-09-04 – 2030-03-31
Emiko NoguchiDepartment of Medical Genetics, Faculty of Medicine, University of TsukubaJapanPrediction of Therapeutic Response to Mite Allergen Immunotherapy2026-06-18 – 2034-03-31