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NBDC Research ID:hum0017-v1
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Research title

Exome sequencing of primary central nervous system lymphoma

Research overview

Aims: Primary central nervous system lymphoma (PCNSL) is a rare type lymphoma confined to the central nervous system. Effective therapies against PCNSL are severely limited. By conducting whole exome sequencing of PCNSL specimens, we aimed to reveal molecular mechanism underlying PCNSL carcinogenesis.

Methods: Genomic DNA was extracted from surgically resected PCNSL tissues and paired peripheral blood, and subjected to Exome analysis. RNA extracted from surgically resected PCNSL tissues was subjected to RNA-seq analysis.

Targets: Forty-one cases diagnosed to have PCNSL

Datasets

Dataset ID
Access type
Type of data
Release date
JGAD000021Controlled-access (Type I)NGS (Exome, RNA-seq)2020-09-28

Data provider

    Principal investigator
    Hiroyuki Mano
    Name
    Division of Cellular Signaling, National Cancer Center Research Institute

Research projects

Name
URL
PCNSL Genomic Analysishttps://www.ncc.go.jp/en/ri/division/genetics/index.html

Grants

Name
Title
Project number
Leading Advanced Projects for medical innovation, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-LEAP)Project for novel therapeutic targets in cancer

    Related publications

    Title
    DOI
    		Dataset ID
    Genomic characterization of primary central nervous system lymphomahttps://doi.org/10.1007/s00401-016-1536-2

    Controlled access users

    Principal Investigator
    Affiliation
    Country/Region
    Research title
    Period of data use
    		Dataset ID
    Adrian Mosquera OrgueiraInsititute for Research in Health at Santiago de Compostela (IDIS)SpainAn integrative analysis of Primary Central Nervous Systema Lymphoma (PCNSL) genomes2017-04-04—2023-08-21
    Hamada MichiakiWaseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05—2027-10-31
    Hua WeiHuashan Hospital, Fudan UniversityChinaGenomic and molecular characterization of primary central nervous system lymphoma2022-06-13—2023-10-11
    Okosun JessicaQueen Mary University of LondonUnited KingdomDissecting the molecular heterogeneity and evolution of central nervous system lymphomas2021-11-11—2026-03-02
    Hattori KeiichiroUniversity of TsukubaJapanIndentification of neuroinflammatory cells supporting the development of primary central nervous system lymphoma2019-02-12—2024-05-01
    Kataoka KeisukeNational Cancer Center Research InstituteJapanA multicenter observational study on prognostic indices for primary central nervous system malignant lymphoma2025-09-02—2027-12-31
    Shipp MargaretDana-Farber Cancer InstituteUSADevelopment of a comprehensive approach to analyze genetic bases for immune evasion in Primary Central Nervous System Lymphoma2017-11-29—2023-08-22
    Saito RyutaNagoya UniversityJapanGenetic analysis during the progression of brain tumors and its impact on tumor microenvironment formation2022-10-13—2027-03-31
    Ogawa SeishiKyoto UniversityJapanAnalysis on the relationship between clonal hematopoiesis and COVID-19 infection.2020-01-09—2022-12-19
    Chiba ShigeruUniversity of TsukubaJapanIndentification of neuroinflammatory cells supporting the development of primary central nervous system lymphoma2019-02-12—2024-05-01
    Iida ShinsukeNagoya City University Graduate School of Medical SciencesJapanWhole Exome Sequencing Analysis of Diffuse Large B-Cell Lymphoma That Progressed to Central Nervous System2024-03-05—2025-04-14
    Wei LiChongqing Institute of Population and Family PlanningChinaMolecular understanding of Primary Central Nervous System Lymphoma (PCNSL) using single cell genomics2016-11-25—2022-11-02