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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0017-v1Release info

Latest

Research title

Exome sequencing of primary central nervous system lymphoma

Research overview

Aims
Primary central nervous system lymphoma (PCNSL) is a rare type lymphoma confined to the central nervous system. Effective therapies against PCNSL are severely limited. By conducting whole exome sequencing of PCNSL specimens, we aimed to reveal molecular mechanism underlying PCNSL carcinogenesis.
Methods
Genomic DNA was extracted from surgically resected PCNSL tissues and paired peripheral blood, and subjected to Exome analysis. RNA extracted from surgically resected PCNSL tissues was subjected to RNA-seq analysis.
Participants/materials
Forty-one cases diagnosed to have PCNSL
URL

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000021NGS (Exome, RNA-seq)
  • WES
  • RNA-seq
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Hiroyuki Mano
Affiliation
Division of Cellular Signaling, National Cancer Center Research Institute

Research projects

Grants

NameTitleProject number
Leading Advanced Projects for medical innovation, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-LEAP)
Project for novel therapeutic targets in cancer
N/A

Related publications

TitleDOIDataset ID
Genomic characterization of primary central nervous system lymphoma
https://doi.org/10.1007/s00401-016-1536-2 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Li WEINational Key Laboratory of Birth Defects and Reproductive Health, Chongqing Institute of Population and Family PlanningChinaMolecular understanding of Primary Central Nervous System Lymphoma (PCNSL) using single cell genomics2016-11-25 – 2022-11-02
Mosquera Orgueira AdrianLymphoproliferative Diseases Research Group, Insititute for Research in Health at Santiago de Compostela (IDIS)SpainAn integrative analysis of Primary Central Nervous Systema Lymphoma (PCNSL) genomes2017-04-04 – 2023-08-21
Margaret ShippDivision of Hematologic Neoplasia, Dana-Farber Cancer InstituteMassachusetts, United StatesDevelopment of a comprehensive approach to analyze genetic bases for immune evasion in Primary Central Nervous System Lymphoma2017-11-29 – 2023-08-22
Shigeru ChibaDepartment of Hematology, University of TsukubaJapanIndentification of neuroinflammatory cells supporting the development of primary central nervous system lymphoma2019-02-12 – 2024-05-01
Seishi OgawaDepartment of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto UniversityJapanComprehensive analysis of genetic alterations in hematological malignancies.2020-01-09 – 2022-12-19
Jessica OkosunBarts Cancer Institute, Queen Mary University of LondonUnited KingdomDissecting the molecular heterogeneity and evolution of central nervous system lymphomas2021-11-11 – 2026-03-02
Wei HuaNeurosurgery, Huashan Hospital, Fudan UniversityChinaGenomic and molecular characterization of primary central nervous system lymphoma2022-06-13 – 2023-10-11
Ryuta SaitoNeurosurgery, Nagoya UniversityJapanGenetic analysis during the progression of brain tumors and its impact on tumor microenvironment formation2022-10-13 – 2027-03-31
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31
Shinsuke IidaHematology and Oncology, Nagoya City University Graduate School of Medical SciencesJapanWhole Exome Sequencing Analysis of Diffuse Large B-Cell Lymphoma That Progressed to Central Nervous System2024-03-05 – 2025-04-14
Keisuke KataokaDivision of Molecular Oncology, National Cancer Center Research InstituteJapanA multicenter observational study on prognostic indices for primary central nervous system malignant lymphoma2025-09-02 – 2027-12-31