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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0600-v1Release info

Latest

Research title

Elucidation of the Molecular Mechanisms of Advanced Thyroid Cancer through Single-Cell Gene Expression Analysis

Research overview

Aims
We will perform single-cell gene expression analysis on advanced thyroid cancer (undifferentiated thyroid carcinoma, poorly differentiated thyroid carcinoma, and advanced or recurrent differentiated thyroid carcinoma) to identify genes involved in the malignant transformation and dedifferentiation of thyroid cancer, and to analyze the characteristics of cell populations that constitute the tumor microenvironment.
Methods
scRNA-seq
Participants/materials
undifferentiated thyroid carcinoma: 3 cases, papillary thyroid carcinoma: 3 cases
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD001086NGS (scRNA-seq)
  • scRNA-seq
Controlled-access (Type I)2026-09-18
E-GEAD-1308NGS (scRNA-seq)
  • scRNA-seq
Unrestricted-access2026-09-07

Data provider

Principal investigator
Akiko Iguchi
Affiliation
Department of Breast and Endocrine Surgery, Institute of Medicine, University of Tsukuba

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (C)
Research for the development of novel immunotherapy for anaplastic thyroid carcinoma
  • JP20K08950

Related publications

TitleDOIDataset ID
Single-cell Transcriptome of Anaplastic Thyroid Cancer Reveals Immunosuppressive Tumor Microenvironment Remodeling
https://doi.org/10.1002/cam4.72261 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.