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NBDC Research ID:hum0561-v1
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Research title

A Prospective Multicenter Study of Exploring Genomic Correlates of Clinical Outcome in Patients with Metastatic Castration-Sensitive Prostate Cancer Receiving Enzalutamide

Research overview

Aims: The association between tumor genomic alterations and clinical outcomes, including clinical and radiographic progression-free survival, PSA response, PSA progression-free survival, overall survival, and time to progression to castration-resistant prostate cancer (CRPC), was investigated in patients with metastatic castration sensitive prostate cancer (mCSPC) treated with the oral nonsteroidal antiandrogen enzalutamide. The findings are expected to contribute to the development of novel therapeutic strategies for personalized medicine in prostate cancer.

Methods: Whole exome sequencing analysis

Targets: 76 mCSPCs prior to enzalutamide treatment

Datasets

Dataset ID
Access type
Type of data
Release date
JGAD001046Controlled-access (Type I)NGS (Exome)2026-05-26

Data provider

    Principal investigator
    Koji Hatano
    Name
    Department of Urology, The University of Osaka Graduate School of Medicine

Research projects

Name
URL
MENZ study group

Grants

Name
Title
Project number
Cancer Clinical Research Grant ProgramA Prospective Multicenter Study of Exploring Genomic Correlates of Clinical Outcome in Patients with Metastatic Castration-Sensitive Prostate Cancer Receiving Enzalutamide
    Astellas fundingA Prospective Multicenter Study of Exploring Genomic Correlates of Clinical Outcome in Patients with Metastatic Castration-Sensitive Prostate Cancer Receiving Enzalutamide

      Related publications

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      Controlled access users

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