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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0561-v1Release info

Latest

Research title

A Prospective Multicenter Study of Exploring Genomic Correlates of Clinical Outcome in Patients with Metastatic Castration-Sensitive Prostate Cancer Receiving Enzalutamide

Research overview

Aims
The association between tumor genomic alterations and clinical outcomes, including clinical and radiographic progression-free survival, PSA response, PSA progression-free survival, overall survival, and time to progression to castration-resistant prostate cancer (CRPC), was investigated in patients with metastatic castration sensitive prostate cancer (mCSPC) treated with the oral nonsteroidal antiandrogen enzalutamide. The findings are expected to contribute to the development of novel therapeutic strategies for personalized medicine in prostate cancer.
Methods
Whole exome sequencing analysis
Participants/materials
76 mCSPCs prior to enzalutamide treatment
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD001046NGS (Exome)
  • WES
Controlled-access (Type I)2026-05-26

Data provider

Principal investigator
Koji Hatano
Affiliation
Department of Urology, The University of Osaka Graduate School of Medicine

Research projects

NameURL
MENZ study group
N/A

Grants

NameTitleProject number
Cancer Clinical Research Grant Program
A Prospective Multicenter Study of Exploring Genomic Correlates of Clinical Outcome in Patients with Metastatic Castration-Sensitive Prostate Cancer Receiving Enzalutamide
N/A
Astellas funding
A Prospective Multicenter Study of Exploring Genomic Correlates of Clinical Outcome in Patients with Metastatic Castration-Sensitive Prostate Cancer Receiving Enzalutamide
N/A

Related publications

No related publications.

Controlled access users

No use of the controlled access data has been recorded.