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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0552-v1Release info

Latest

Research title

Study to elucidate the association between clonal hematopoiesis and abdominal aortic aneurysm

Research overview

Aims
Abdominal aortic aneurysm(AAA) is a localized dilation of the abdominal aorta that may rupture and cause sudden death. In Japan, "aortic aneurysm and dissection" ranks around the 10th leading cause of mortality. Recent studies have shown that clonal hematopoiesis (CH), an age-related expansion of hematopoietic stem cells carrying somatic mutations in genes such as DNMT3A, TET2, ASXL1, PPM1D, JAK2, SF3B1, SRSF2, and TP53, can promote atherosclerosis and thrombosis, contributing to cardiovascular disease. While such mutations are common in patients with atherosclerotic disease and heart failure, their role in AAA remains unclear. This study aims to establish an AAA patient database and clarify how CH affects disease severity and treatment response.
Methods
target capture sequencing
Participants/materials
Forty-four patients underwent their first surgical repair for abdominal aortic aneurysm at Nagoya University Hospital. AAA (including both fusiform and saccular types) is defined as an abdominal aortic diameter of ≥3 cm on CT imaging.
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD001007NGS (Target Capture)
  • Targeted DNA sequencing
Controlled-access (Type I)2025-12-24

Data provider

Principal investigator
Yoshimitsu Yura
Affiliation
Department of Cardiology, Nagoya University School of Medicine

Research projects

NameURL
Clonal Hematopoiesis & Cardiovascular Disease Project
N/A

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Early-Career Scientists
Mechanistic elucidation of how clonal hematopoiesis modifies cardiovascular disease
  • 24K19026
Fusion Oriented REsearch for disruptive Science and Technology (FOREST) program, Japan Science and Technology Agency (JST)
Elucidation of the pathophysiology of age-associated cardiovascular disease mediated by clonal hematopoiesis
  • JPMJFR2217

Related publications

TitleDOIDataset ID
Tet2-Clonal Hematopoiesis Drives Aortic Aneurysm via Macrophage-to-Osteoclast-like Differentiation
https://doi.org/10.1172/jci198708 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.