Skip to content
NBDC Human Database

No datasets in the cart.

Go to the cart

Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0536-v1Release info

Latest

Research title

Genomic Analysis and Exploration of Therapeutic Targets in Malignant Pleural Mesothelioma and Related Diseases

Research overview

Aims
Malignant pleural mesothelioma is an aggressive pleural tumor with poor prognosis. Understanding the molecular mechanisms underlying its development and progression is essential for improving diagnosis and treatment. This study aims to identify clinically relevant molecular pathways through genomic and transcriptome analyses of tumor and non-tumor pleural tissues. Candidate genes associated with tumor initiation and progression will be analyzed in terms of gene expression, localization, dynamics, and cell-to-cell interactions. Their correlation with clinicopathological parameters will also be investigated. Tumor tissues will be preserved by cryopreservation or transplantation into immunodeficient mice to enable further studies using in vivo models or in vitro cell culture systems.
Methods
WGS, single-cell RNA-seq, ATAC-seq
Participants/materials
One pleural mesothelioma patient
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD001002NGS (WGS, scRNA-seq, ATAC-seq)
  • WGS
  • scRNA-seq
  • ATAC-seq
Controlled-access (Type I)2026-04-09

Data provider

Principal investigator
Shumpei Ishikawa
Affiliation
Department of Preventive Medicine, Graduate School of Medicine, The University of Tokyo

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (S)
A New Definition of Heterogeneity in Gastric Cancer through Quantitative Integration of Spatial Tissue and Genomic Information
  • 22H04990
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)
Trajectory Analysis of Genomic and Pathological Information during the Treatment Course of Refractory Cancers
  • JP24ck0106904
KAKENHI Grant-in-Aid for Scientific Research (B)
Elucidation of a Novel Neutrophil-Tumor Interaction in Diffuse-Type Gastric Cancer
  • 23K27436
KAKENHI Grant-in-Aid for JSPS Fellows
Mechanistic Dissection of Tumor-Stromal Interactions and Identification of Therapeutic Targets in Malignant Pleural Mesothelioma
  • 23KJ0836

Related publications

TitleDOIDataset ID
Cooperative Response Loops Enhanced by Histamine Signaling during Tumor-Neutrophil Crosstalk in Pleural Mesothelioma
https://doi.org/10.1016/j.celrep.2026.117361 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.