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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0522-v1Release info

Latest

Research title

Immune regulation by cotrolling regulatory T cell-specific epigenome

Research overview

Aims
To address the dynamics of immune checkpoint inhibitor (ICI)-bound progenitor-exhausted T cells after ICI treatment and analysis of immune cells in autoimmune diseases
Methods
scRNA-seq, TCR-seq, CITE-seq
Participants/materials
Esophagogastric junction cancer 2 cases, gastric cancer 3 cases
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000853NGS (scRNA-seq, TCR-seq, CITE-seq)
  • scRNA-seq
  • TCR-seq
  • CITE-seq
Controlled-access (Type I)2025-06-27

Data provider

Principal investigator
Takuro Saito
Affiliation
Department of gastroenterological surgery, Osaka University

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Early-Career Scientists
Immune status of lymph nodes in gastric cancer and the effect of checkpoint inhibitors on lymph nodes
  • 23K15472
KAKENHI Grant-in-Aid for Early-Career Scientists
The analysis for the suppressive mechanism of antitumor immunity in lymph nods of gastric cancer
  • 20K17685
KAKENHI Grant-in-Aid for Scientific Research (C)
Elucidating the Mechanism of effect of Immune Checkpoint Inhibitors Through Detection of Nivolumab-Bound T Cells
  • 23K08194
Medical research grant, Takeda Science Foundation
Mechanistic Insights into Antitumor Lymphocyte Regulation in Gastric Cancer by Spatial Mapping of Lymph Nodes
N/A
Medical research grant, Chubei Itoh Foundation
N/A
N/A

Related publications

TitleDOIDataset ID
PD-1 antibody-bound progenitor-exhausted CD8+ T cells in lymph nodes boost PD-1-blockade anti-tumor immunity in gastrointestinal cancer
https://doi.org/10.1038/s41467-026-70751-2 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.