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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0497-v1Release info

Latest

Research title

Isolation and characterization of trophoblast stem cells from human placenta

Research overview

Aims
Establishing trophoblast stem cells from the human term placenta contributes to elucidating the pathophysiology of placenta-related pregnancy complications, such as preeclampsia, which commonly occur in late pregnancy.
Methods
RNA sequencing
Participants/materials
Three trophoblast stem cell (Ch-TS) lines derived from the chorion of term placentas from three individuals, as well as differentiated extravillous trophoblast cells (Ch-EVT) and syncytiotrophoblast cells (Ch-ST). Additionally, three trophoblast stem cell lines obtained from RIKEN BRC (CT27, CT29, bTS5) and their differentiated extravillous trophoblast cells and syncytiotrophoblast cells.
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000919NGS (RNA-seq)
  • RNA-seq
Controlled-access (Type I)2025-08-08

Data provider

Principal investigator
Masatsugu Ema
Affiliation
Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (C)
Establishment of trophoblast stem cells derived from patients with hypertensive disorders of pregnancy
  • 22K09639
KAKENHI Grant-in-Aid for Challenging Research (Pioneering)
Elucidation of implantation and placental development mechanisms in non-human primates and their application to human biology
  • 24K21265
KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Inner cell mass dynamism and totipotency in primate
  • 22H04669
KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Origin of placental tissues in cynomolgus monkey
  • 20H05359
The Seiichi Imai Memorial Foundation
Generation of Trophoblast Stem Cell from Preeclampsia
N/A

Related publications

TitleDOIDataset ID
Establishment of Human Trophoblast Stem Cells from Term Smooth Chorion
https://doi.org/10.1016/j.placenta.2025.07.090 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.