HumanDBs

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NBDC Research ID:hum0497-v1

Release info

Latest

Title

Isolation and characterization of trophoblast stem cells from human placenta

Research overview

Aims: Establishing trophoblast stem cells from the human term placenta contributes to elucidating the pathophysiology of placenta-related pregnancy complications, such as preeclampsia, which commonly occur in late pregnancy.

Methods: RNA sequencing

Targets: Three trophoblast stem cell (Ch-TS) lines derived from the chorion of term placentas from three individuals, as well as differentiated extravillous trophoblast cells (Ch-EVT) and syncytiotrophoblast cells (Ch-ST). Additionally, three trophoblast stem cell lines obtained from RIKEN BRC (CT27, CT29, bTS5) and their differentiated extravillous trophoblast cells and syncytiotrophoblast cells.

Datasets

	Dataset ID	Access type	Type of data	Release date
	JGAD000919	Controlled-access (Type I)	NGS (RNA-seq)	2025-08-08

Data provider

Principal Investigator: Masatsugu Ema
Affiliation: Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science

Research projects

Name	URL
No data

Grants

Name	Title	Project number
KAKENHI Grant-in-Aid for Scientific Research (C)	Establishment of trophoblast stem cells derived from patients with hypertensive disorders of pregnancy	22K09639
KAKENHI Grant-in-Aid for Challenging Research (Pioneering)	Elucidation of implantation and placental development mechanisms in non-human primates and their application to human biology	24K21265
KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)	Inner cell mass dynamism and totipotency in primate	22H04669
KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)	Origin of placental tissues in cynomolgus monkey	20H05359
The Seiichi Imai Memorial Foundation	Generation of Trophoblast Stem Cell from Preeclampsia

Related publications

Title	DOI	Datasets
Establishment of Human Trophoblast Stem Cells from Term Smooth Chorion	https://doi.org/10.1016/j.placenta.2025.07.090	JGAD000919

Controlled access users

Principal Investigator	Affiliation	Country/Region	Research title	Period of data use	Data in use (Dataset ID)
No data