Research ID
hum0492-v1Release info
Latest
Research title
Exploratory research aimed at developing new drugs for difficult-to-treat immune-inflammatory diseases through industry-academia collaboration
Research overview
- Aims
- Although advances in our understanding of the disease mechanisms and the development of new drugs has improved the prognosis for patients with immune-inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease and autoimmune liver disease, there are still some patients who do not respond well to treatment or who are unable to discontinue the use of steroid drugs. This study aims to identify biomarkers, such as genes and proteins, that can be also used as new therapeutic targets in the blood and tissues of patients with these immune-inflammatory diseases who are starting new treatment.
- Methods
- Single cell RNA sequencing/TCR/BCR repertoire analyses, Spatial transcriptome analysis (Visium)
- Participants/materials
- labial salivary glands from 28 patients with Sjögren's syndrome and 10 patients with Sicca
- URL
- N/A
Datasets
| Cart | Dataset ID | Type of data | Analysis method | Access criteria | Date published |
|---|---|---|---|---|---|
| JGAD000915 | NGS (scRNA-seq/TCR/BCR repertoire) NGS (Visium Spatial Gene Expression), Histological image |
| Controlled-access (Type I) | 2025-08-13 |
Data provider
- Principal investigator
- Masaru Takeshita
- Affiliation
- Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine
Research projects
No research projects.
Grants
| Name | Title | Project number |
|---|---|---|
KAKENHI Grant-in-Aid for Early-Career Scientists | Single cell integrated analysis of antigen specificity and gene expression for the cure of autoimmune diseases |
|
KAKENHI Grant-in-Aid for Scientific Research (C) | Elucidation of the Mechanisms of Autoantibody Production at Lesion Sites in Autoimmune Diseases |
|
KAKENHI Grant-in-Aid for JSPS Fellows | Elucidation of Sjögren's syndrome pathogenesis through retrotransposon sequences |
|
KAKENHI Grant-in-Aid for Scientific Research (B) | Molecular signatures in pre-RA patients by multi-omics analysis |
|
Keio University Academic Promotion Fund | Elucidation of Autoimmune Mechanisms at Lesion Sites in Autoimmune Diseases and Development of Antigen-Specific Immunosuppressive Therapies | N/A |
Keio University Fukuzawa Memorial Fund | Comprehensive Understanding of Autoimmunity and Practical Application of Antigen-Specific Immunosuppressive Therapies | N/A |
Keio University Next-Generation Research Promotion Program | Comprehensive Analysis of Salivary Gland Lesions as Sites of Autoimmune Responses | N/A |
Mochida Memorial Foundation for Medical and Pharmaceutical Research - Research Grant - | lucidation of Autoimmune Mechanisms in Lesional Tissues of Sjögren's Syndrome and Development of Antigen-Specific Immunosuppressive Therapies | N/A |
Kowa Life Science Foundation - Research Grant - | Elucidation of Molecular Mechanisms Involved in Autoimmune Responses at Lesion Sites in Sjögren's Syndrome | N/A |
Takeda Science Foundation - Medical Research Grant - | Elucidation of Autoimmune Mechanisms at Lesion Sites in Autoimmune Diseases | N/A |
Japan Rheumatism Foundation - Research Grant for Rheumatic Disease Investigation - | Elucidation of Molecular Mechanisms Involved in Autoantigen-Specific B Cell Immune Responses in Various Autoimmune Diseases and Identification of Therapeutic Targets | N/A |
Related publications
No related publications.
Controlled access users
| Principal investigator | Affiliation | Country/Region | Research title | Period of data use | Dataset ID |
|---|---|---|---|---|---|
| Michiaki Hamada | Hamada Laboratory, Faculty of Science and Engineering, Waseda University | Japan | Construction of RNA-targeted Drug Discovery Database | 2023-01-05 – 2027-10-31 |