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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0491-v1Release info

Latest

Research title

Elucidating molecular mechanisms of allergy

Research overview

Aims
Germinal center reactions in secondary lymphoid tissues are those responsible for the production of high-affinity antibodies and are primarily regulated by CD4+ T cells. However, the biology of CD4+ T cells in secondary lymphoid tissues has not been well described in humans. In particular, the differentiation, localization, and heterogeneity of IL10+ Foxp3- follicular CD4+ T cells (T follicular regulatory type 1, Tfr1 cells), which suppress the germinal center response, remain unresolved. This study aims to describe CD4+ T cells in human secondary lymphoid tissues in detail and to elucidate the differentiation, localization and heterogeneity of IL10+ Foxp3- follicular CD4+ T cells.
Methods
CD4+ T cells (whole or Tfr1-enriched) were isolated from tonsil specimens by FACS and subjected to the following single-cell multi-omics analyses: scRNA-seq, scRNA-TCR-seq, scATAC-RNA-seq. In some experiments, CITE-seq was combined.
Participants/materials
Chronic tonsillitis 8 cases
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000947NGS (scRNA-seq, scRNA-TCR-seq, scATAC-RNA-seq)
  • scRNA-seq (± CITE-seq)
  • scRNA-seq + scTCR-seq (± CITE-seq)
  • scATAC-seq + scRNA-seq
Controlled-access (Type I)2025-07-07
E-GEAD-1086processed data of JGAS000805 / JGAD000947
Read count data of NGS (scRNA-seq, scRNA-TCR-seq, scATAC-RNA-seq)
TCR repertoire clonotype data
open chromatin region data
  • scRNA-seq (± CITE-seq)
  • scRNA-seq + scTCR-seq (± CITE-seq)
  • scATAC-seq + scRNA-seq
Unrestricted-access2025-07-03

Data provider

Principal investigator
Hideki Ueno
Affiliation
Department of Immunology, Graduate School of Medicine, Kyoto University

Research projects

No research projects.

Grants

No grants.

Related publications

TitleDOIDataset ID
Single-cell multiomic analysis revealed the differentiation, localization, and heterogeneity of IL10+ Foxp3- follicular T cells in humans.
https://doi.org/10.1093/intimm/dxaf014 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31