Skip to content
NBDC Human Database

No datasets in the cart.

Go to the cart

Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0461-v2Release info

Latest

Research title

Analysis of the cancer immune response following radiation therapy for esophageal squamous cell carcinoma and colorectal cancer

Research overview

Aims
Radiotherapy (RT) is pivotal in cancer care, with 50 to 60% of patients receiving it. Traditionally, RT's primary mechanism was deemed to induce lethal DNA damage. However, recent findings unveil contributions from immune responses and immunological cell death to its anti-tumor efficacy. Since RT alone has limitations in maximizing these effects, novel strategies to activate immune responses are sought. Despite trials combining RT with immune checkpoint inhibitors (ICIs), optimal combinations remain elusive. This study aims to elucidate post-RT dynamics of cancer immune responses and gene expression profiles, aiming to optimize both immunotherapy and radiotherapy.
Methods
【scRNA-seq】single cell sequencing by illumima
【Spatial transcriptome seq】Spatial transcriptome sequencing Visium
【Multiplex fluorescence immunostaining】Multiplex fluorescence immunostaining by CODEX (Akoya Biosciences)
Participants/materials
【scRNA-seq】esophageal squamous cell carcinoma: 5 cases
【Spatial transcriptome seq】esophageal squamous cell carcinoma: 2 cases
【Multiplex fluorescence immunostaining】esophageal squamous cell carcinoma: 2 cases
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000845NGS (scRNA-seq)
NGS (Visium Spatial Gene Expression), Histological image
  • scRNA-seq
  • Multiplex Fluorescence Immunostaining
  • Visium 空間トランスクリプトーム + 病理画像
Controlled-access (Type I)2024-05-30

Data provider

Principal investigator
Shun-Ichiro Kageyama
Affiliation
Department of Radiation Oncology, National Cancer Center Hospital East

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (C)
Analysis of the Non-coding RNA Pathway in Radiation-induced Immune Responses
  • 21K07582
KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas
Platform for Advanced Genome Sciences
  • 16H06279
KAKENHI Grant-in-Aid for Transformative Research Areas
Platform for Advanced Genome Sciences
  • 22H04925

Related publications

TitleDOIDataset ID
Comprehensive single-cell analysis demonstrates radiotherapy-induced infiltration of macrophages expressing immunosuppressive genes into tumor in esophageal squamous cell carcinoma
https://doi.org/10.1126/sciadv.adh9069 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31