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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0445-v2Release info

Latest

Research title

Cancer genomics for elucidation of molecular mechanisms of carcinogenecis and progression in lung cancer

Research overview

Aims
The objective of this project is to analyze genomic aberrations and gene expression changes such as mutations, deletions, amplifications, and hypermethylation in human lung cancer cells at the somatic cell level, and to contrast these with clinicopathological information to elucidate the molecular mechanisms and characteristics of lung cancer development and progression at the genetic level.
Methods
RNA-seq, Whole exome sequencing
Participants/materials
Lung adenocarcinoma, Non-small cell lung cancer
URL

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000897NGS (RNA-seq)
  • RNA-seq
  • WES
Controlled-access (Type I)2025-05-21

Data provider

Principal investigator
Takashi Kohno
Affiliation
Division of Genome Biology, National Cancer Center Research Institute

Research projects

No research projects.

Grants

NameTitleProject number
The Advanced Research for Medical Products Mining Program of the National Institute of Biomedical Innovation (NIBIO)
Research aimed at a comprehensive exploration of drug targets based on genomic data in multi-layered disease omics analysis
  • 157974
The Health, and Labor Sciences Research Expenses for Commission
Research on the establishment of a new treatment for advanced non-small cell lung cancer with RET fusion
  • 201409013B
KAKENHI Grant-in-Aid for Scientific Research (B)
Study on molecular procedures developing oncogene fusion-positive lung cancer
  • 26293200

Related publications

TitleDOIDataset ID
KIF5B-RET fusions in lung adenocarcinoma
https://doi.org/10.1038/nm.2644 (opens in a new tab)
Development of lung adenocarcinomas with exclusive dependence on oncogene fusions
https://doi.org/10.1158/0008-5472.CAN-14-3282 (opens in a new tab)
Druggable Oncogene Fusions in Invasive Mucinous Lung Adenocarcinoma
https://doi.org/10.1158/1078-0432.CCR-14-0107 (opens in a new tab)
Passive Smoking-Induced Mutagenesis as a Promoter of Lung Carcinogenesis
https://doi.org/10.1016/j.jtho.2024.02.006 (opens in a new tab)
Genomic Profiles of Pathogenic and Moderate-Penetrance Germline Variants Associated With Risk of Early-Onset Lung Adenocarcinoma
https://doi.org/10.1016/j.jtho.2025.06.005 (opens in a new tab)
Mutation of CMTR2 in Lung Adenocarcinoma Alters RNA Alternative Splicing and Reveals Therapeutic Vulnerabilities
https://doi.org/10.1038/s41467-025-64821-0 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.