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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0440-v1Release info

Latest

Research title

Elucidation of proteins associated with the clinical course of refractory neuromuscular diseases using nerve and muscle tissue

Research overview

Aims
The primary causes of neurodegenerative diseases, as well as peripheral nerve disorders like autoimmune encephalitis and chronic inflammatory demyelinating polyneuropathy, remain unclear. Although numerous therapeutic drugs have been developed for the conditions at hand, it is known that even within the same neurological and muscular diseases, there are differences in clinical progression and initial symptoms among individual patients. We aim to identify proteins related to this clinical progression and develop treatment strategies tailored to the pathology.
Methods
10x Visium FFPE with CytAssist
Participants/materials
Thymoma, Thymic hyperplasia
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000802NGS (Visium Spatial Gene Expression), Histological image
  • Visium 空間トランスクリプトーム + 病理画像
Controlled-access (Type I)2024-05-30
E-GEAD-747NGS (Visium Spatial Gene Expression), Histological image
  • Visium 空間トランスクリプトーム + 病理画像
Unrestricted-access2024-05-15

Data provider

Principal investigator
Tatsusada Okuno
Affiliation
Department of Neurology, Osaka University Graduate School of Medicine

Research projects

NameURL
Elucidation of proteins associated with the clinical course of refractory neuromuscular diseases using nerve and muscle tissue
N/A

Grants

NameTitleProject number
Grants-in-Aid for Scientific Research Grant (B)
Trial to elucidate of the pathogenesis of autoimmune neuromuscular diseases and catalogue their treatment
  • 23H02826

Related publications

TitleDOIDataset ID
Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis thymoma
https://doi.org/10.1101/2024.02.05.579042 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.