Skip to content
NBDC Human Database

No datasets in the cart.

Go to the cart

Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0391-v1Release info

Latest

Research title

Establishment of a human tongue cancer organoid biobank

Research overview

Aims
In cancer treatment using chemotherapeutic agents, a few chemotherapy-resistant cancer cells survive and cause cancer recurrence. These cancer cell subpopulations with anticancer drug-resistant properties called "persister" tumor cells. Therefore, elucidating the molecular basis of persistent tumor generation and establishing eradication strategies of them will aid of many cancer patients. In this study, we use single-cell Multiome analysis (10X Genomics) of a uniquely established human tongue cancer organoid library to characterize persister tumor cell properties based on their gene expression profile and chromatin accessibility.
Methods
scMultiome (10x Genomics) analysis
Participants/materials
Tongue cancer organoids established from tumor tissues of tongue cancer patients
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000735NGS (scRNA-seq, scATAC-seq)
  • scRNA-seq + scATAC-seq
Controlled-access (Type I)2024-09-25

Data provider

Principal investigator
Taku Sato
Affiliation
Department of Biodefence Research, Medical Research Institute, Tokyo Medical and Dental University / Department of Biochemistry and Molecular Biology, Nippon Medical School Graduate School of Medicine

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Transformative Research Areas
Platform for Advanced Genome Sciences
  • 22H04925

Related publications

TitleDOIDataset ID
Comparative analysis of organoids derived from tongue cancer patients identifies the heritable nature of minimal residual disease
https://doi.org/10.1016/j.devcel.2024.10.007 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.