hum0352-v1Release info

Analytical study of protein function and RNA expression involved in predicting treatment efficacy and adverse event development in lung cancer radiotherapy

Aims

To elucidate the functions of DNA repair proteins and RNA expression that are involved in the therapeutic efficacy and adverse events of radiotherapy for lung cancer. In particular, this is an exploratory study to identify proteins and RNAs involved in the expression of proteins that are likely to be involved in the prediction of radiotherapy response and adverse events.

Methods

Peripheral blood samples were collected from the patients with lung cancer who gave consent for this study. RNA-sequencing analysis was performed with the RNAs extracted from the blood samples.

Participants/materials

Patients who have undergone radiotherapy for primary lung cancer at our hospital between 2019 and 2020 will be considered. Among them, we will include cases in which it is possible to determine the effect of treatment and evaluate adverse events before and, and whose blood can be drawn at 3 points: before radiotherapy, at the end of treatment, and 2-4 weeks after treatment.

URL

N/A

Principal investigator

Masanori Someya

Affiliation

Department of Radiology, Sapporo Medical University, School of Medicine

No research projects.

No use of the controlled access data has been recorded.