Skip to content
NBDC Human Database

No datasets in the cart.

Go to the cart

Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0342-v3Release info

Latest

Research title

Immunohistochemical and molecular pathological search in gastrointestinal tumors

Research overview

Aims
Recent advances in somatic mutation and expression analysis in tumors have revealed the molecular pathological background of various gastrointestinal tumors. In the future, it is expected that these findings will be used to improve the accuracy of histopathological and grade diagnoses, as well as to further advance such searches. In this study, we conducted an integrated analysis of somatic mutations, gene expression, and protein expression, mainly in gastrointestinal tumors. By correlating these findings with histopathological and clinicopathological findings, we will search for new tissue-specific markers and prognostic factors that can be applied to histopathological and molecular pathological diagnoses.
Methods
Whole exome sequencing (WES) was conducted using tumor and non-tumor tissues obtained from RSPO fusion-positive cases. Whole exome sequencing (WES) and transcriptome analysis (RNA-seq) were conducted using tumor and non-tumor tissues obtained from small intestine cancer cases. Also RNA-seq were conducted using tumor obtained from colorectal cancer cases.
Participants/materials
colorectal cancer, small intestine cancer
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000657NGS (Exome)
  • WES
Controlled-access (Type I)2022-05-27
JGAD001011NGS (Exome, RNA-seq)
  • WES
  • RNA-seq
Controlled-access (Type I)2026-01-06
JGAD001018NGS (RNA-seq)
  • RNA-seq
Controlled-access (Type I)2026-01-30

Data provider

Principal investigator
Shigeki Sekine
Affiliation
Department of Diagnostic Pathology, National Cancer Center Hospital

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (C)
Clinicopathological analysis of RSPO fusion-positive colorectal carcinoma
  • 20K07382
Kurozumi Medical Foundation
Efficient detection of RSPO gene fusion/overexpression in colorectal and gastric cancers using RNA in situ hybridization
N/A

Related publications

TitleDOIDataset ID
Clinicopathological and molecular characteristics of RSPO fusion-positive colorectal cancer
https://doi.org/10.1038/s41416-022-01880-w (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31