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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0338-v1Release info

Latest

Research title

Comprehensive cancer genome, epigenome, and immunogenome analysis for gastric cancer unaffected by aging or Helicobacter pylori infection

Research overview

Aims
Comprehensive genome data for advanced gastric cancer have already been accumulated, widely published, and available including the Cancer Genome Atlas (TCGA) published in 2014 and the Asian Cancer Research Group (ACRG) in 2015. Aging and inflammation associated with H. pylori (HP) is an important risk factor for gastric cancer. HP shows evidence of infection in most gastric cancer patients. However, there are also a small number of juvenile and HP-negative gastric cancers, and the details of their genomic profile are unknown. This study narrows down to a patient population without factors such as aging and HP infection to elucidate the molecular abnormalities essential to new carcinogenesis and cancer progression, search for new therapeutic targets and to analyze the function of them to verify their biological significance in vitro and in vivo.
Methods
Whole Exome Sequencing Analysis
Participants/materials
H. Pylori uninfected gastric cancer: 27 patients, H. Pylori infected gastric cancer: 36 patients
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000701NGS (Exome)
  • WES
Controlled-access (Type I)2022-11-24

Data provider

Principal investigator
Seiichi Mori
Affiliation
Cancer Precision Medicine Center, Japanese Foundation for Cancer Research

Research projects

No research projects.

Grants

NameTitleProject number
Takeda Japan Medical Office Funded Research Grant
N/A
N/A

Related publications

TitleDOIDataset ID
Genomic features of Helicobacter pylori-naïve diffuse-type gastric cancer
https://doi.org/10.1002/path.6000 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.