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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0320-v1Release info

Latest

Research title

Immunomonitoring study in patients with malignant tumors

Research overview

Aims
Various immunocompetent cells and factors in the peripheral blood cells and tumor tissues of patients with malignant tumors were analyzed. The immunological status of patients with malignant tumors will be clarified by analyzing various immune cells and factors in peripheral blood cells and tumor tissues. The relationship between immune status and clinicopathological characteristics, molecular biological characteristics, therapeutic effects, and prognosis will be evaluated as well.
Methods
Expressions of CD4, CD8, FoxP3, CD25, CD45RA, CTLA-4, PD-1, ICOS, BTLA, Tim-3, LAG3, CCR7, and other molecules on immunocompetent cells (CD4/CD8 T cells, antigen-presenting cells, regulatory T cells, MDSCs, spontaneous lymphocytes, etc.) were analyzed by single-cell sequencing technology. The T-cell receptor (TCR) of immune cells was also analyzed in the same technology.
Participants/materials
pulmonary gland cancer: 2 cases, head and neck part cancer: 3 cases
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000597NGS (scRNA-seq, TCR-seq)
  • scRNA-seq
  • TCR-seq
Controlled-access (Type I)2022-01-24

Data provider

Principal investigator
Yosuke Togashi
Affiliation
Chiba Cancer Center Research Institute

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (B)
Analysis of PD-1+ tumor-infiltrating T cells according to cancer antigen hierarchy
  • 20H03694
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)
Spatial and temporal analysis of neoantigen-specific T-cell clones as a therapeutic target and biomarker
  • JP19ck0106521
Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)
Novel tumor-infiltrating T cell analysis according to antigen epitope
  • JP18cm0106340
Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)
Development of a single-cell analysis method for tumor-infiltrating lymphocytes with genomic abnormalities and elucidation of its clinical significance
  • JP21cm0106383

Related publications

TitleDOIDataset ID
PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes
https://doi.org/10.1016/j.celrep.2022.110331 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Ansuman SatpathyDepartment of Pathology, Stanford UniversityUnited StatesEpigenetics of Inflammatory Skin Disorders2022-07-13 – 2023-11-06
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31