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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0305-v1Release info

Latest

Research title

A multicenter study of biological and genetic manifestations of subsequent solid cancers after hematopoietic cell transplantation

Research overview

Aims
Subsequent solid cancers after allogenic hematopoietic cell transplantation may have unique genomic profiles compared with de novo cancers. In order to identify such profiles, we applied whole exome sequencing (WES) of subsequent solid cancers after allogeneic hematopoietic cell transplantation as well as de novo cancers.
Methods
Genomic DNA was extracted using a QIAamp Fast DNA Tissue kit, GeneRead DNA FFPE kit or QIAamp DNA Mini kit. Libraries for WES were prepared using the Twist library preparation kit. The libraries were sequenced using a Novaseq 6000 or DNBSEQ G400 with the paired-end option.
Participants/materials
14 fresh-frozen tumor tissues and 14 formalin-fixed-paraffin-embedded (FFPE) tumor tissues of 14 de novo cancer patients
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000491NGS (Exome)
  • WES
Controlled-access (Type I)2021-11-04

Data provider

Principal investigator
Yoshihiro Inamoto
Affiliation
Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital

Research projects

NameURL
Comprehensive molecular profiling of subsequent solid cancers after allogenic hematopoietic cell transplantation
N/A

Grants

NameTitleProject number
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)
Establishment of personalized medicine for secondary solid tumors after hematopoietic cell transplantation based on genomic characterization
  • JP20ck0106539

Related publications

TitleDOIDataset ID
MicroSEC filters sequence errors for formalin-fixed and paraffin-embedded samples
https://doi.org/10.1038/s42003-021-02930-4 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.