Skip to content
NBDC Human Database

No datasets in the cart.

Go to the cart

Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0304-v1Release info

Latest

Research title

Exome sequencing of human breast cancer tissues resistant to taxanes.

Research overview

Aims
Taxanes are key drugs in the treatment of breast cancer, but some breast cancers are resistant to taxanes. We used whole exome-sequencing (WES) technology to investigate mechanisms of taxane resistance in human breast cancer.
Methods
DNAs extracted from tumor tissues and peripheral blood cells of patients with breast cancer whose tumors responded well to anthracycline treatment but grew rapidly during neoadjuvant taxane-based chemotherapy were used for WES analysis and somatic mutations in the candidate genes were identified.
Participants/materials
Six patients with breast cancer whose tumors grew rapidly during neoadjuvant taxane-based chemotherapy
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000484NGS (Exome)
  • WES
Controlled-access (Type I)2022-11-16

Data provider

Principal investigator
Yumi Wanifuchi-Endo
Affiliation
Department of Breast Surgery, Graduate School of Medical Sciences, Nagoya City University

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (C)
Exome sequencing analysis in human breast cancer tissues showing resistance for taxanes.
  • 16K10469

Related publications

TitleDOIDataset ID
Discovering novel mechanisms of taxane resistance in human breast cancer by whole-exome sequencing
https://doi.org/10.3892/ol.2021.13178 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.