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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0301-v1Release info

Latest

Research title

An integrative analysis study of genomic abnormalities and immune status in breast cancer patients and high-risk individuals (Immuno-Genome Atlas Project)

Research overview

Aims
To clarify the relationship between genomic abnormalities and immune status in cancer patients and high-risk individuals, we analyzed various immunocompetent cells/factors (immunological profile) in tumor tissues, normal mammary tissue, and peripheral blood cells for genetic mutations. The relationship between immune status and clinicopathological/biological features, treatment response, and prognosis were examined as a secondary endpoint.
Methods
For target sequence, genomic DNA was extracted using QIAamp DNA Mini Kits or QIAamp Fast DNA Tissue Kit for fresh-frozen samples and GeneRead DNA FFPE Kit for formalin-fixed-paraffin-embedded (FFPE) samples.
Participants/materials
Tumor tissues and normal breast tissues from 26 patients with breast cancer (fresh frozen samples and FFPE samples)
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000482NGS (Target Capture)
  • Targeted DNA sequencing
Controlled-access (Type I)2021-11-26

Data provider

Principal investigator
Hiroyuki Mano
Affiliation
Division of Cellular Signaling, National Cancer Center Research Institute

Research projects

NameURL
Immuno-Genome Atlas Project (iGAP)
N/A

Grants

NameTitleProject number
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)
Implementation of precision medicine by the application of an innovative method for functional evaluation of oncogenes.
  • JP19ck0106252

Related publications

TitleDOIDataset ID
MicroSEC filters sequence errors for formalin-fixed and paraffin-embedded samples
https://doi.org/10.1038/s42003-021-02930-4 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.