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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0300-v1Release info

Latest

Research title

Whole-genome and whole-exome analyses of cancer

Research overview

Aims
We perform integrative genome-wide analyses such as whole-exome sequencing, epigenome analysis, copy number variant (CNV) analysis, and gene expression analysis using next-generation sequencing and other methods to elucidate driver genes and signaling pathways causing tumorigenesis and cancer progression, leading novel molecular diagnostics and molecular therapies.
Methods
Whole-exome sequencing, RNA-sequencing
Participants/materials
Whole-exome sequencing, Esophageal squamous cell carcinoma, tumor and paired non-tumor, 88 pairs; RNA-sequencing, Esophageal squamous cell carcinoma, tumor and paired non-tumor, 57 pairs
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000481NGS (Exome, RNA-seq)
  • WES
  • RNA-seq
Controlled-access (Type I)2021-11-30

Data provider

Principal investigator
Johji Inazawa
Affiliation
Department of molecular cytogenetics, Medical Research Institute, Tokyo Medical and Dental University

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Establishment of novel concept for cancer diagnostics and therapeutics based on the systematic comprehension of cellular context in cancer
  • 15H05908
Project for Development of Innovative Research on Cancer Therapeutics (P-DIRECT), Japan Agency for Medical Research and Development (AMED)
Identification of novel therapeutic target molecules and diagnostic biomarkers for esophageal squamous cell carcinoma
  • JP15cm0106067
Tailor-Made Medical Treatment with the BioBank Japan Project (BBJ), Japan Agency for Medical Research and Development (AMED)
Research and development for tailor-made cancer treatment based on integrative genome analyses
  • JP17km0506001
Tokyo Medical and Dental University, Nanken-Kyoten
N/A
N/A

Related publications

TitleDOIDataset ID
Integrative genome-wide analyses reveal the transcriptional aberrations in Japanese esophageal squamous cell carcinoma
https://doi.org/10.1111/cas.15063 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31
Satoshi FujiiMolecular pathology, Yokohama City UniversityJapanA observational study to control the accuracy of PD-L1 immunohistochemistry and to elucidate the biological significance of the staining affinity in squamous cell carcinoma across multiple organs2025-10-07 – 2026-07-23