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NBDC Research ID:hum0300-v1

Release info

Latest

Title

Whole-genome and whole-exome analyses of cancer

Research overview

Aims: We perform integrative genome-wide analyses such as whole-exome sequencing, epigenome analysis, copy number variant (CNV) analysis, and gene expression analysis using next-generation sequencing and other methods to elucidate driver genes and signaling pathways causing tumorigenesis and cancer progression, leading novel molecular diagnostics and molecular therapies.

Methods: Whole-exome sequencing, RNA-sequencing

Targets: Whole-exome sequencing, Esophageal squamous cell carcinoma, tumor and paired non-tumor, 88 pairs; RNA-sequencing, Esophageal squamous cell carcinoma, tumor and paired non-tumor, 57 pairs

Datasets

	Dataset ID	Access type	Type of data	Release date
	JGAD000481	Controlled-access (Type I)	NGS (Exome, RNA-seq)	2021-11-30

Data provider

Representative: Johji Inazawa
Organiation: Department of molecular cytogenetics, Medical Research Institute, Tokyo Medical and Dental University

Research projects

Name	URL
No data

Grants

Name	Title	Project number
KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)	Establishment of novel concept for cancer diagnostics and therapeutics based on the systematic comprehension of cellular context in cancer	15H05908
Project for Development of Innovative Research on Cancer Therapeutics (P-DIRECT), Japan Agency for Medical Research and Development (AMED)	Identification of novel therapeutic target molecules and diagnostic biomarkers for esophageal squamous cell carcinoma	JP15cm0106067
Tailor-Made Medical Treatment with the BioBank Japan Project (BBJ), Japan Agency for Medical Research and Development (AMED)	Research and development for tailor-made cancer treatment based on integrative genome analyses	JP17km0506001
Tokyo Medical and Dental University, Nanken-Kyoten

Related publications

Title	DOI	Datasets
Integrative genome-wide analyses reveal the transcriptional aberrations in Japanese esophageal squamous cell carcinoma	https://doi.org/10.1111/cas.15063	JGAD000481

Controlled access users

Name	Organiation	Country	Research title	Period of data use	Datasets
Hamada Michiaki	Waseda University	Japan	Construction of RNA-targeted Drug Discovery Database	2023-01-05—2027-10-31	JGAD000481
Fujii Satoshi	Yokohama City University	Japan	A observational study to control the accuracy of PD-L1 immunohistochemistry and to elucidate the biological significance of the staining affinity in squamous cell carcinoma across multiple organs	2025-10-07—2026-07-23	JGAD000481