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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0286-v2Release info

Latest

Research title

Elucidation of molecular mechanism of NAFLD-HCC

Research overview

Aims
To elucidate the interaction between cancer cells and immune cells in the tumor immune microenvironment of non-viral hepatocellular carcinoma
Methods
Visium Spatial Gene Expression Assay, Target Capture Sequencing Analysis
Participants/materials
Visium Spatial Gene Expression Assay: Four samples containing a fat-containing hepatocellular carcinoma (HCC) tissue#1, a non-tumor tissue of fat-containing HCC tissue#2, a fat-containing HCC tissue#3, and a fat-not containing HCC tissue#4. #1 and #2 are tissues derived from the same patient.
Target Capture Sequencing Analysis: Tumor tissues and non-tumor tissues of 55 hepatocellular carcinoma patients
URL

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000422NGS (Visium Spatial Gene Expression), Histological image
  • Visium 空間トランスクリプトーム + 病理画像
Controlled-access (Type I)2022-09-13
JGAD000642NGS (Target Capture)
  • Targeted DNA sequencing
Controlled-access (Type I)2022-11-15

Data provider

Principal investigator
Takahiro Kodama
Affiliation
Dept. Gastroenterology and Hepatology, Graduate School of Medicine, Osaka University

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas
Platform for Advanced Genome Science
  • 16H06279

Related publications

TitleDOIDataset ID
Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma
https://doi.org/10.1002/hep.32573 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.