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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0280-v1Release info

Latest

Research title

The research for the identification of neoantigen and tumor immune microenvironment in lung cancer

Research overview

Aims
To evaluate the tumor immune microenvironment (TIME) of lung cancer to develop a new immune based therapy.
Methods
We carried out RNA sequencing (RNA-seq) on 113 tumor tissues from patients with lung cancer. To evaluate the tumor immune microenviroment (TIME), we calculated the score (T-score; Glycolysis, Mitotic spindle, I-score; T cells, B cells, MHC-complex, S-score; angiogenesis, hypoxia, epithelial mesenchymal transition, cytokine production suppression) using single sample Gene Set Enrichment Analysis (ssGSEA).
Participants/materials
We enrolled a total of 113 patients with lung cancer who underwent lung resection from August 2019 to June 2021 and obtained the fresh tumor samples.
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
DRA012560NGS (RNA-seq)
  • RNA-seq
Unrestricted-access2022-01-07

Data provider

Principal investigator
Hirokazu Matsushita
Affiliation
Division of Translational Oncoimmunology, Aichi Cancer Center Research Institute

Research projects

NameURL
Identification of target antigens and analysis of cancer microenvironments in lung cancer patients
N/A

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (C)
Investigation of Immunogenic cell death related to chemotherapy in circulating tumor cells
  • 20K09187
KAKENHI Grant-in-Aid for Scientific Research (B)
Specific immune responses against tumor antigens in long term survivors of cancer
  • 19H03528
Japanese Respiratory Foundation
The identification of CD4 positive cytotoxic T cell as a new target for immune-based therapy
N/A

Related publications

No related publications.