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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0274-v1Release info

Latest

Research title

Integrated analysis of selective mRNA export by mRNA export factors, UAP56 and URH49

Research overview

Aims
mRNA exporters, NXF1 and CRM1, are known to function in mRNA export. However, since each target mRNA has not been identified genome-widely, it is not clear whether they export exclusive mRNA subsets. To reveal this point, we prepared the nuclear and the cytoplasmic RNAs under either exporter inhibited condition and carried out RNA-seq.
Methods
Knockdown of a target gene was performed in cultured human cells (HeLa), and RNA was extracted after fractionation into the nucleus and cytoplasm.
Participants/materials
HeLa cells with knockdown of the target gene
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000401NGS (RNA-seq)
  • RNA-seq
Controlled-access (Type I)2022-04-14

Data provider

Principal investigator
Kenichi Fujita
Affiliation
Division of Gene Expression Mechanism, Fujita Healthy University

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Early-Career Scientists
Integrated analysis of selective mRNA export by mRNA export factors, UAP56 and URH49
  • 19K15807

Related publications

TitleDOIDataset ID
MPP6 stimulates both RRP6 and DIS3 to degrade a specified subset of MTR4-sensitive substrates in the human nucleus
https://doi.org/10.1093/nar/gkac559 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31