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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0269-v2Release info

Latest

Research title

Sensitive gene analysis of hereditary cardiovascular disease

Research overview

Aims: Elucidation of the pathophysiology of patients with hereditary cardiovascular disease
Methods: Whole exome sequencing analysis and RNA-seq analysis
Participants/materials: hereditary cardiovascular disease
URL: http://www.cardiology.med.osaka-u.ac.jp/?page_id=37180 (opens in a new tab)

Datasets

Cart	Dataset ID	Type of data	Analysis method	Access criteria	Date published
	JGAD000402	NGS (Exome, RNA-seq)	WES RNA-seq	Controlled-access (Type I)	2021-05-24
	JGAD000691	NGS (Exome)	WES	Controlled-access (Type I)	2024-03-19
	JGAD000692	NGS (Exome)	WES	Controlled-access (Type I)	2024-03-19
	JGAD000693	NGS (Exome)	WES	Controlled-access (Type I)	2024-03-19

Data provider

Principal investigator: Yoshihiro Asano
Affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University

Research projects

Name	URL
Molecular Genetics and Drug Discovery Group	http://www.cardiology.med.osaka-u.ac.jp/?page_id=34297 (opens in a new tab)

Grants

Name	Title	Project number
KAKENHI Grant-in-Aid for Scientific Research (B)	Identification of de novo molecular targets and drug discovery by genome analysis and trans-omics analysis of hereditary cardiomyopathy	19H03652
KAKENHI Grant-in-Aid for Scientific Research (B)	Functional and informatics integration analysis based on whole genome analysis platform and identification of novel cardiomyopathy genes and elucidation of their mechanisms	22H03067
Research Center Network for Realization of Regenerative Medicine, Japan Agency for Medical Research and Development (AMED)	Development of Autologous Skeletal Myoblast Cell Sheet Transplantation for Dilated Cardiomyopathy Aiming Precision Medicine	JP22bm040070
Research Center Network for Realization of Regenerative Medicine, Japan Agency for Medical Research and Development (AMED)	Drug discovery via development of multidisciplinary drug screening system by using disease specific-iPS cells derived from refractory cardiomyopathy	JP22bm0804008

Related publications

Title	DOI	Dataset ID
Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation	https://doi.org/10.1126/scitranslmed.abf3274 (opens in a new tab)	JGAD000402

Controlled access users

Principal investigator	Affiliation	Country/Region	Research title	Period of data use	Dataset ID
Michiaki Hamada	Hamada Laboratory, Faculty of Science and Engineering, Waseda University	Japan	Construction of RNA-targeted Drug Discovery Database	2023-01-05 – 2027-10-31	JGAD000402