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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0242-v1Release info

Latest

Research title

Frequent post-treatment monitoring of colorectal cancer using individualized ctDNA validated by multi-regional molecular profiling

Research overview

Aims
To evaluate clinical validity of circulating tumor DNA (ctDNA) of tumor-unique mutations identified from colorectal cancer tissues, as a personalized tumor marker.
Methods
Pre- and post-operational plasma, primary tumor, and peripheral blood mononuclear cells (PBMCs) were collected from 12 enrolled patients. Among these patients, two patients had two separate colorectal tumors. The primary tumor specimens were taken from three regions immediately after the operation, and the cellularity of all specimens was microscopically confirmed to be >30%. DNA was extracted from 42 primary tumor specimens and 12 PBMCs, and target sequencing using a HiSeq 2000 System (Illumina) conducted for 151 genes that have been implicated in a wide range of cancers was performed.
Participants/materials
Colorectal cancer patients with preoperative diagnosis of Stage III or higher. Individual written consent was obtained from each participant.
URL

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000343NGS (Target Capture)
  • Targeted DNA sequencing
Controlled-access (Type I)2021-01-06

Data provider

Principal investigator
Satsoshi Nishizuka
Affiliation
Division of Biomedical Research and Development, Iwate Medical University Institute for Biomedical Sciences

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Establishment of selection process of molecular targeting drugs in response to biological heterogeneity in drug-resistant cancer cells
  • 16H01578
KAKENHI Fund for the Promotion of Joint International Research (Fostering Joint International Research)
Identification of compounds that potentially lead to the cancer relapse suppression on the basis of drug-resistant cancer subpopulation model (original)
  • 15KK0317
KAKENHI Grant-in-Aid for Scientific Research (C)
Circumvent practical issues for introducing ctDNA into daily practice
  • 19K09224
KAKENHI Grant-in-Aid for Scientific Research (C)
Effect of immune response to Helicobacter pylori on adjuvant chemotherapy for gastric cancer
  • 19K09130
KAKENHI Grant-in-Aid for Scientific Research (C)
Development of monitoring system for esophageal cancer by quantifying circulating tumor DNA
  • 17K10605
KAKENHI Grant-in-Aid for Young Scientists (B)
Development of longitudinal monitoring system for gastrointestinal cancer using circulating tumor DNA
  • 18K15326
KAKENHI Grant-in-Aid for Young Scientists (B)
The new estimation method of recurrence and metastasis on circulating tumor DNA detection in colorectal cancer patients
  • 16K19951
Keiryoukai Research Grant
Development of precision medicine for esophageal cancer patients using circulating tumor mutational DNA
  • 136
JSPS Fujita Memorial Fund for Medical Research
Impact of intratumor heterogeneity for ctDNA of colon cancer
N/A
Iwate Prefectural Regional Innovation Grant
Development of high-sensitive individualized tumor markers for quantitative evaluation of advanced cancer
N/A

Related publications

No related publications.

Controlled access users

No use of the controlled access data has been recorded.