HumanDBs

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NBDC Research ID:hum0236-v1

Release info

Latest

Research title

Development of tumor infiltrating lymphocytes therapy targeting gene mutation of lung cancer

Research overview

Aims: Identifying aberrant splicing isoforms and potential neoantigens in non-small cell lung cancer

Methods: Full-length cDNA sequencing using a long-read sequencer MinION, short-read RNA sequencing, and whole-exome sequencing were performed to detect aberrant splicing isoforms and neoantigens expressed in non-small cell lung cancer specimens.

Targets: Seven non-small cell lung cancer specimens (tumor and matched-non tumor pair)

Datasets

	Dataset ID	Access type	Type of data	Release date
	JGAD000345	Controlled-access (Type I)	NGS (Exome) NGS (RNA-seq [MinION]) NGS (RNA-seq [HiSeq 2500])	2020-12-10

Data provider

Principal investigator: Tetsuya Nakatsura
Name: Division of Cancer Immunotherapy, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center

Research projects

Name	URL
No data

Grants

Name	Title	Project number
KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas	Platform for Advanced Genome Science	16H06279
Grant-in-Aid for Early-Career Scientists	Development of novel measurement methods for RNA synthesis and degradation using nanopore sequencing	19K16108
Grant-in-Aid for Early-Career Scientists	Development of novel methods for detection of neoantigens in cancers by full-length transcriptome sequencing using nanopore sequencers	19K16792

Related publications

Title	DOI	Dataset ID
No data

Controlled access users

Principal Investigator	Affiliation	Country/Region	Research title	Period of data use	Dataset ID
Deng Youping	University of Hawaii Manoa	USA	Identification of driver genes and somatic mutations for lung cancer diagnosis and prognosis	2018-10-04—2029-07-10	JGAD000345
Hamada Michiaki	Waseda University	Japan	Construction of RNA-targeted Drug Discovery Database	2023-01-05—2027-10-31	JGAD000345
Nakaoka Hirofumi	Kagoshima University Graduate School of Medical and Dental Sciences	Japan	Analysis of hypomorphic variants in breast cancer-associated genes by using large-scale sequencing data sets	2022-08-17—2026-07-23	JGAD000345
Kohno Takashi	National Cancer Center Research Institute	Japan	Identification of genetic risk factors in AYA(Adolescence and Young Adult) cancer	2021-12-02—2028-12-31	JGAD000345