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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0236-v1Release info

Latest

Research title

Development of tumor infiltrating lymphocytes therapy targeting gene mutation of lung cancer

Research overview

Aims
Identifying aberrant splicing isoforms and potential neoantigens in non-small cell lung cancer
Methods
Full-length cDNA sequencing using a long-read sequencer MinION, short-read RNA sequencing, and whole-exome sequencing were performed to detect aberrant splicing isoforms and neoantigens expressed in non-small cell lung cancer specimens.
Participants/materials
Seven non-small cell lung cancer specimens (tumor and matched-non tumor pair)
URL

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000345NGS (Exome)
NGS (RNA-seq [MinION])
NGS (RNA-seq [HiSeq 2500])
  • WES
  • RNA-seq
Controlled-access (Type I)2020-12-10

Data provider

Principal investigator
Tetsuya Nakatsura
Affiliation
Division of Cancer Immunotherapy, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas
Platform for Advanced Genome Science
  • 16H06279
Grant-in-Aid for Early-Career Scientists
Development of novel measurement methods for RNA synthesis and degradation using nanopore sequencing
  • 19K16108
Grant-in-Aid for Early-Career Scientists
Development of novel methods for detection of neoantigens in cancers by full-length transcriptome sequencing using nanopore sequencers
  • 19K16792

Related publications

No related publications.

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Youping DengDepartment of Complementary & Integrative Medicine, University of Hawaii ManoaHawaii, United StatesIdentification of driver genes and somatic mutations for lung cancer diagnosis and prognosis2018-10-04 – 2029-07-10
Takashi KohnoDivision of Genome Biology, National Cancer Center Research InstituteJapanIdentification of genetic risk factors in AYA(Adolescence and Young Adult) cancer2021-12-02 – 2028-12-31
Hirofumi NakaokaDepartment of Cancer Genome Research, Sasaki InstituteJapanGenetic analysis of lung cancer2022-08-17 – 2026-07-23
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31