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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0233-v1Release info

Latest

Research title

Paediatric Hepatic International Tumour Trial (JPLT4: PHITT)

Research overview

Aims
To characterize the genomic profile of hepatoblastoma and hepatocellular carcinoma and then to compare these data to clinical course of the patients for development of novel treatment strategies accoding to tumor biological characteristics
Methods
Whole Exome Sequencing (NGS), RNA-seq (NGS), SNP array, Methylation array, Whole Genome Bisulfite Sequencing (NGS)
Participants/materials
165 clinical hepatoblastoma samples
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000334NGS (Exome)
NGS (RNA-seq)
SNP array
Methylation array
NGS (WGBS)
  • WES
  • RNA-seq
  • Genotyping by array
Controlled-access (Type I)2021-06-04

Data provider

Principal investigator
Eiso Hiyama
Affiliation
Natural Science Center for Basic Research and Development, Hiroshima University

Research projects

NameURL
JPLT-2 project / Japanese study group for Pediatric Liver Tumor (JPLT)

Grants

NameTitleProject number
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)
Development of standard treatments for childhood embryonal solid tumors
  • JP18CK0106332
Project Promoting Clinical Trials for Development of New Drugs, Japan Agency for Medical Research and Development (AMED)
Clinical international collaboration trials for drug development in childhood liver tumors under the nationwide childhood cancer registry
  • JP18LK0201066
Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)
Elucidation of initiation and progression mechanism of human epithelial tumors towards identification of novel therapeutic targets
  • JP19cm0106502
Tailor-Made Medical Treatment with the BioBank Japan Project (BBJ), Japan Agency for Medical Research and Development (AMED)
Establishment of a Biobank and Creation of a Database of Clinical Information
  • JP16km0305001
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)
Identification of new diagnostic biomarkers and development of new therapeutic strategies in intractable childhood malignant solid tumors
  • JP16ck0106070
KAKENHI Grant-in-Aid for Scientific Research (A)
Cancer fluid biopsy for childhood malignancies using one cell analysis
  • 15H02567
KAKENHI Grant-in-Aid for Scientific Research (A)
Study of clinical states and infrastructure development of International co-operative clinical trial for childhood liver tumors by children's cancer study group
  • 16H02778
KAKENHI Grant-in-Aid for Scientific Research (A)
Next-generation cancer liquid biopsy of childhood cancers using single cell analysis
  • 19H01056

Related publications

No related publications.

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Jinyan HuangZhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China. Biomedical big data center, the First Affiliated Hospital, Zhejiang UniversityChinaComprehensive analysis of alternative splicing in malignant tumors2022-03-15 – 2024-01-01
Weng Chuan PengResearch, Princess Maxima Center for Pediatric OncologyNetherlandsTowards understanding pediatric liver tumors2023-08-21 – 2027-06-01
Tianzhong YangChildhood Cancer Genomic Group Division of Biostatistics, University of MinnesotaMinnesota, United StatesEvaluating germline genetic risk factors of hepatoblastoma onset and survival2022-09-26 – 2025-09-03
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31
Yujie TangDepartment of Histoembryology, Genetics and Developmental Biology, College of Basic Medical Sciences, Shanghai Jiao Tong UniversityChinaThe key molecular mechanisms underlying the oncogenesis and progression of neuroblastoma and hepatoblastoma2023-03-08 – 2027-12-31
Xin ChenCancer Biology Program, University of Hawaii Cancer CenterHawaii, United StatesWnt/beta-Catenin or Hippo/YAP target gene expression in hepatoblastoma2023-04-25 – 2025-05-26
Hiroki HiraoDepartment of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical SciencesJapanSOX9 expression analysis in Hepatoblastoma2024-04-16 – 2026-03-31
Naiyang FuACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical ResearchVictoria, AustraliaMOLECULAR PROFILING OF HUMAN AND MOUSE LIVER TUMOUR DATASETS (MHMT)2026-04-27 – 2028-11-01