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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0225-v1Release info

This page is a past version (v1). The latest version is v2.
Latest version (v2)

Research title

Mortality and risk of progression to adult T-cell leukemia/lymphoma in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis

Research overview

Aims
Estimating the risks of developing adult T-cell leukemia (ATL) through a genetic analysis of human T-cell leukemia virus (HTLV-1)-associated myelopathy (HAM)
Methods
Target capture sequencing, RNA-seq, ATAC-seq, single-cell Multiome (scRNA-seq, scATAC-seq)
Participants/materials
Target capture: HAM 21 cases (infected and uninfected cells)
RNA-seq: HAM 13 cases (infected cells)
ATAC-seq: HAM 2 cases (infected cells)
scMultiome: HAM 2 cases, asymptomatic HTLV-1 carriers 3 individuals
URL
N/A

Datasets

The list is the one this version published; each dataset's content is shown as it is now.

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000318NGS (Target Capture)
  • Targeted DNA sequencing
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Makoto Yamagishi
Affiliation
Graduate School of Frontier Sciences, The University of Tokyo
Principal investigator
Yoshihisa Yamano
Affiliation
Institute of Medical Science, St. Marianna University School of Medicine

Research projects

NameURL
Laboratory of Viral Oncology and Genomics / Department of Rare Disases Research
N/A

Grants

NameTitleProject number
Research Program on Emerging and Re-emerging Infectious Diseases, Japan Agency for Medical Research and Development (AMED)
Development of risk stratification and prevention for HTLV-1-associated diseases based on multi-omics database
  • JP20fk0108126
KAKENHI Grant-in-Aid for Scientific Research (B)
Analysis of genome/epigenome control mechanism that regulates abnormal traits of HTLV-1 infected cells in HAM
  • 19H03575
Practical Research Project for Rare / Intractable Diseases, Japan Agency for Medical Research and Development (AMED)
The establishment of evidence for clinical guideline development on HAM and HTLV-1-related refractory disease through integration of patient registry
  • JP19ek0109356
Research Program on Emerging and Re-emerging Infectious Diseases, Japan Agency for Medical Research and Development (AMED)
Comprehensive study on elucidation of pathogenesis of HTLV-1 infection based on genome information and development of risk prediction algorithm
  • JP25fk0108672

Related publications

TitleDOIDataset ID
Mortality and risk of progression to adult T-cell leukemia/lymphoma in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis
https://doi.org/10.1073/pnas.1920346117 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Masao MatsuokaFaculty of Life Sciences Department of Hematology, Rheumatology and Infectious Diseases, Kumamoto UniversityJapanRetrospective observational study of characteristics, clinical course and treatment of malignant lymphoma and adult T-cell leukemia/lymphoma with genetic and pathological evaluations2022-05-18 – 2030-03-31
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31