Research ID
hum0216-v2Release info
This page is a past version (v2). The latest version is v4.
Latest version (v4)Research title
Analyses of immune status of patients with solid tumors including gastrointestinal cancer / Investigation of anti-tumor immunological response in solid tumors
Research overview
- Aims
- To elucidate immune status of solid tumors including gastrointestinal cancer and to investigate tumor mutation burden for clarification of anti-tumor immuno-response.
- Methods
- whole exome sequencing analysis
- Participants/materials
- 17 patients with lung adenocarcinomas who underwent surgery from 2015-2016
40 patients with malignancies who received PD-1 blackade therapy from 2017 to 2019
23 patients with gastric cancers who underwent surgery from 2015 to 2016
7 patients with colorectal cancer - URL
- N/A
Datasets
The list is the one this version published; each dataset's content is shown as it is now.
| Cart | Dataset ID | Type of data | Analysis method | Access criteria | Date published |
|---|---|---|---|---|---|
| JGAD000302 | NGS (Exome) |
| Controlled-access (Type I) | 2020-09-28 | |
| JGAD000327 | NGS (Exome) |
| Controlled-access (Type I) | 2021-03-29 | |
| JGAD000344 | NGS (Exome) |
| Controlled-access (Type I) | 2020-09-28 |
Data provider
- Principal investigator
- Hiroyoshi Nishikawa
- Affiliation
- Division of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center
Research projects
No research projects.
Grants
| Name | Title | Project number |
|---|---|---|
The National Cancer Center Research and Development Fund | Establishment of an advanced system of immune monitoring |
|
The National Cancer Center Research and Development Fund | Development of novel treatment for immunotherapy-resistant cancer |
|
Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED) | Establishment of predictive methods for cancer immunotherapy based on the evaluation of cancer cells and immune responses |
|
Related publications
| Title | DOI | Dataset ID |
|---|---|---|
Blockade of EGFR improves responsiveness to PD1 blockade in EGFR-mutated non-small cell lung cancer | ||
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies | ||
Importance of lymph node immune responses in MSI-H/dMMR colorectal cancer |
Controlled access users
| Principal investigator | Affiliation | Country/Region | Research title | Period of data use | Dataset ID |
|---|---|---|---|---|---|
| Youping Deng | Department of Complementary & Integrative Medicine, University of Hawaii Manoa | Hawaii, United States | Identification of driver genes and somatic mutations for lung cancer diagnosis and prognosis | 2018-10-04 – 2029-07-10 | |
| Takashi Kohno | Division of Genome Biology, National Cancer Center Research Institute | Japan | Identification of genetic risk factors in AYA(Adolescence and Young Adult) cancer | 2021-12-02 – 2028-12-31 | |
| Hirofumi Nakaoka | Department of Cancer Genome Research, Sasaki Institute | Japan | Genetic analysis of lung cancer | 2022-08-17 – 2026-07-23 | |
| Takuya Yamamoto | Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition | Japan | Basic research for vaccine development against gastrointestinal cancer and malignant melanoma based on the identification of novel cancer antigens | 2024-11-12 – 2026-03-31 |