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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0206-v1Release info

Latest

Research title

Establishment and characterization of cell lines derived from pregnancy related diseases

Research overview

Aims
A complete hydatidiform mole (CHM) is an abnormal pregnancy caused by genetic fertilization disorders. The aim of this study is to establish human trophoblast stem (TS) cell lines from CHMs and elucidate their pathogenesis.
Methods
Transcriptome analysis (RNA-seq) , Methyloation analysis (PBAT-seq)
Participants/materials
Cytotrophoblast (CT) cells isolated from placenta tissues of CHMs and CHM-derived TS cells
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000292NGS (PBAT-seq, RNA-seq)
  • PBAT-seq
  • RNA-seq
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Takahiro Arima
Affiliation
Department of Informative Genetics, Tohoku University Graduate School of Medicine

Research projects

No research projects.

Grants

NameTitleProject number
Core Research and Evolutional Science and Technology, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-CREST)
Elucidation of the mechanisms underlying human placental development and design of a placenta-on-a-chip platform
  • JP19gm1310001
Core Research and Evolutional Science and Technology, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-CREST)
Epigenome analysis of cells in the placenta and endometrium forming the fetal-maternal interface
  • JP17gm0510011

Related publications

TitleDOIDataset ID
Loss of p57KIP2 expression confers resistance to contact inhibition in human androgenetic trophoblast stem cells
https://doi.org/10.1073/pnas.1916019116 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31