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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0202-v1Release info

Latest

Research title

Study of genetic background and time course of congenital hearing loss to increase efficacy of auditory, speech, and language therapy.

Research overview

Aims
To analyze genetic background of congenital to prelingual childhood-onset hearing loss to increase efficacy of auditory, speech, and language therapy.
Methods
DNA samples extracted from peripheral blood samples of prelingual childhood-onset hearing loss patients and their parents were subjected for subsequent genomic analyses. Auditory tests were also underwent.
Participants/materials
Patients and their parents
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000493NGS (Exome)
  • WES
Controlled-access (Type I)2021-11-05

Data provider

Principal investigator
Tatsuo Matsunaga
Affiliation
Division of Hearing and Balance Research, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center

Research projects

No research projects.

Grants

NameTitleProject number
KEKENHI Gran-in-Aid for Scientific Research (C)
Molecular functional analysis of ZBTB10, the novel candidate deafness gene associated with cochlear nerve hypoplasia
  • 15K10773
KEKENHI Gran-in-Aid for Scientific Research (C)
Molecular, Cellular, and in vivo analysis of SLC12A2, a novel candidate of deafness gene
  • 18K09336
Tailor-Made Medical Treatment with the BioBank Japan Project (BBJ), Japan Agency for Medical Research and Development (AMED)
Multi-Centered Genome-Associated Research for Congenital Hearing Loss and H7N9 Vaccine and Development of the Sample Banking System to BBJ for the Collected Samples
  • JP15km0305011
National Hospital Organization Collaborative Clinical Research
Study of Genetic Background and Time Course of Congenital Hearing Loss to Increase Efficacy of Auditory, Speech, and Language Therapy.
  • H27-NHO(感覚)-02

Related publications

TitleDOIDataset ID
Variants Encoding a Restricted Carboxy-Terminal Domain of SLC12A2 Cause Hereditary Hearing Loss in Humans
https://doi.org/10.1371/journal.pgen.1008643 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.