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Research ID

hum0181-v1Release info

Latest
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Research title

Aging of steroid production in the adrenal bland.

Research overview

Aims
Immunohistochemistry of human aldosterone synthase (CYP11B2) has revealed that most of aldosterone is autonomously produced in aldosterone-producing cell clusters (APCCs) beneath the capsule of adult adrenals rather than physiologically in the zona glomerulosa (ZG)¹. APCCs have been occasionally found to harbor a somatic mutation of ion channel/pump genes, and number and size of APCCs increase with age until 50 years old², were reported so far. In this study, we aimed to study if APCCs are increased in individuals older than 50 years where the reninangiotensin system (RAS) is generally suppressed due to aging.
1: J Clin Endocrinol Metab 2010;95,2296-305, 2: Int J Endocrinol 2016;7834356
Methods
Archival adrenal gland were immunohistochemically analyzed using antibodies for aldosterone-synthase (CYP11B2) and 3β-hydroxysteroid dehydrogenase (3β-HSD). APCC areas per whole adrenal area (AA / WAA) and number of APCC per whole adrenal area (NOA / WAA) were measured and used for statistical analyses.
Participants/materials
85 anatomical individuals in the Saitama Medical University Hospital, who died at ages from 50 to 103 years.
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
NHA000087histological data (Immunostaining for CYP11B2, 3β-HSD, hematoxylin and eosin staining)
  • 組織画像 (副腎免疫染色・HE 染色)
Unrestricted-access2019-09-25

Data provider

Principal investigator
Koshiro Nishimoto
Affiliation
Saitama Medical University International Medical Center, Department of UroOncology

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (C)
Elucidation of progression from aldosterone-producing cell cluster leading to aldosterone-producing adenoma
  • 15K10650
KAKENHI Grant-in-Aid for Scientific Research (C)
Novel therapeutic strategies for primary aldosteronism by focusing on steroidogenesis
  • 18K09205
KAKENHI Grant-in-Aid for Scientific Research (C)
Mechanisms for development of culprit lesions in primary aldosteronism that exhibits somatic mosaicism
  • 17K09890
Yamaguchi Endocrine Research Foundation Grant
アルドステロン産生腺腫発生の分子基盤解明
N/A
Okinaka Memorial Institute for Medical Research Grant
アルドステロン産生腺腫に判明したイオンチャネル・ポンプ遺伝子体細胞変異が腺腫形成に関与する分子基盤の解明
N/A

Related publications

TitleDOIDataset ID
Expression of aldosterone synthase cyp11b2 was inversely correlated with longevity.
https://doi.org/10.1016/j.jsbmb.2019.04.010 (opens in a new tab)
N/A
Development of monoclonal antibodies against the human 3beta-hydroxysteroid dehydrogenase/isomerase isozymes.
https://doi.org/10.1016/j.steroids.2017.08.011 (opens in a new tab)
N/A