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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0145-v1Release info

Latest

Research title

The genetic analysis of circulating tumor DNA in blood of the digestive cancer patients to investigate the prognostic factors of metastasis and reccurence.

Research overview

Aims
To identify the biomarkers of predicting metastasis and reccurence in colorectal cancer (CRC).
Methods
Genomic DNAs were extracted from several samples (as shown below) and performed a target capture deep sequencing analysis by using of the HaloPlex Cancer Research Panel.
1) Tumor tissues obtained from 3-5 locations in the primary tumor by endoscopic biopsy prior to neoadjuvant chemotherapy (NAC)
2) Tumor tissues and adjacent normal intestinal mucosa (non-tumor tissues) obtained from fresh-frozen surgically resected specimens after NAC and resecting metastais lesions, if patients were experienced recurrence
3) Blood samples obtained from patients at the time of surgery
Participants/materials
Ten colorectal cancer patients with locally advanced primary tumors who underwent primary tumor resection following NAC
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000313NGS (Target Capture)
  • Targeted DNA sequencing
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Koshi Mimori
Affiliation
Department of Surgery, Kyushu University Beppu Hospital

Research projects

No research projects.

Grants

NameTitleProject number
The Shinnihon Foundation of Advanced Medical Treatment Research (2017)
Construction of precision medicine about neoadjuvant chemotherapy for hepatic metastasis of colorectal cancer by using comprehensive gene aberration analysis and mathematical simulation.
N/A

Related publications

TitleDOIDataset ID
Serial mutational tracking in surgically resected locally advanced colorectal cancer with neoadjuvant chemotherapy.
https://doi.org/10.1038/s41416-018-0208-5 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.