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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0143-v1Release info

Latest

Research title

Aberrant (pro)renin receptor expression induces genomic instability by chromatin remodeler SMARCA5 disruption during the pancreatic ductal adenocarcinoma

Research overview

Aims
The aim of the present study is to elucidate whether aberrant (P)RR expression induces genomic instability in human pancreatic ductal epithelial (HPDE) cells, which are transforming into pancreatic ductal adenocarcinoma (PDAC).
Methods
Comparative analysis of the human whole genome between HPDE cells overexpressed by(pro)renin receptor and control HPDE cells
Participants/materials
Immortalized human pancreatic ductal epithelial (HPDE) cells
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000212NGS (WGS)
  • WGS
Controlled-access (Type I)2025-05-13

Data provider

Principal investigator
Akira Nishiyama
Affiliation
Department of Pharmacology, Faculty of Medicine, Kagawa Universty

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (B)
Kidney-mediated aging process
  • 18H03191
KAKENHI Grant-in-Aid for Scientific Research (C)
Evolutionary machanism of pancreatic ductal adenocarcinoma mediated by (pro)renin receptor
  • 19K07690
KAKENHI Grant-in-Aid for challenging Exploratory Research
Functional analysis of (pro)renin receptor in the genesis of pancreatic cancer
  • 16K14610
Hoansha Foundation and Alumni Association of Kagawa University (Sanjukai)
Development of new therapeutic agents for lifestyle-related diseases
N/A
TOBIRA, Tokyo Biomarker Innovation Research Associate
Examination of the availability of soluble (pro)renin receptor as an early marker of pancreatic cancer
N/A

Related publications

TitleDOIDataset ID
Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H
https://doi.org/10.1038/s42003-020-01434-x (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.