Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0141-v1Release info

Latest

Research title

Immune regulation by cotrolling regulatory T cell-specific epigenome

Research overview

Aims: Analysis of immune regulation in head and neck cancer
Methods: RNA-seq
Participants/materials: Head and neck cancer
URL: http://www.med.nagoya-cu.ac.jp/immunol.dir/new1.html (opens in a new tab)

Datasets

Cart	Dataset ID	Type of data	Analysis method	Access criteria	Date published
	JGAD000204	NGS (RNA-seq)	RNA-seq	Controlled-access (Type I)	2020-09-28

Data provider

Principal investigator: Shimon Sakaguchi
Affiliation: Experimental Immunology, IFReC, Osaka University

Research projects

Name	URL
Department of Immunology, Nagoya City University Graduate School of Medical Sciences	http://www.med.nagoya-cu.ac.jp/immunol.dir/new1.html (opens in a new tab)

Grants

Name	Title	Project number
KAKENHI Grant-in-Aid for challenging Exploratory Research	Investigating the mechanisms of regulatory T cell expansion by aging	26670192
KAKENHI Grant-in-Aid for challenging Exploratory Research	Investigating regulatory T cells in skin rare cancer to predict effectiveness of a new immunotherapy	16K15259
KAKENHI Grant-in-Aid for Scientific Research (B)	Research on regulatory T cell-therapy without inducing cancer and severe infections-the safe and effective immunosuppression from Japan	16H05177
KAKENHI Grant-in-Aid for Scientific Research (C)	Developing C5a antagonists specific for oral cancer and investigating mechanisms of cancer proliferation (M.I.)	17K11679
KAKENHI Grant-in-Aid for Young Scientists (B)	Investigating roles of regulatory T cells in inducing anti-tumur immunity and developing immunotherapy in head and neck cancer (T.M.)	17K16937
KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)	Developing a new therapy for autoimmnue dieseases using regulatory T cell and neo-self induced by ultraviolet	17H05798

Related publications

Title	DOI	Dataset ID
Regulatory T cells expressing abundant CTLA-4 on the cell surface with a proliferative gene profile are key features of human head and neck cancer.	https://doi.org/10.1002/ijc.32024 (opens in a new tab)	JGAD000204

Controlled access users

Principal investigator	Affiliation	Country/Region	Research title	Period of data use	Dataset ID
Michiaki Hamada	Hamada Laboratory, Faculty of Science and Engineering, Waseda University	Japan	Construction of RNA-targeted Drug Discovery Database	2023-01-05 – 2027-10-31	JGAD000204