Research ID

hum0127-v2Release info

This page is a past version (v2). The latest version is v4.

Research title

Implementation of individualized medicine for cancer patients by multiomics-based analyses - the Project HOPE (High-tech Omics-based Patients Evaluation) for Cancer Therapy

Research overview

Aims: clarify the molecular profiling and sequential somatic mutation shift in hypermutator tumors harborig POLE mutations
Methods: DNAs and RNAs extracted from peripheral blood cells, tumor and non-tumor tissues are analyzed by whole-exome sequencing, DNA amplicon sequencing, RNA amplicon sequencing and Microarray.
Participants/materials: JGAS000130: 91 hypermutated solid tumors that obtained from patients who take surgeries to remove cancers at the Shizuoka Cancer Center Hospital
JGAS000274: Fresh frozen tumors and blood cells obtained from 5143 cancer patients who take surgeries to remove cancers at the Shizuoka Cancer Center Hospital
URL: https://www.scchr.jp/en/institute/projecthope.html (opens in a new tab)

Datasets

The list is the one this version published; each dataset's content is shown as it is now.

Cart	Dataset ID	Type of data	Analysis method	Access criteria	Date published
	JGAD000141	NGS (Exome)	WES	Controlled-access (Type I)	2020-09-28
	JGAD000380	NGS (Exome; somatic mutation) NGS (Exome; germline mutation) NGS (Exome; CNV) NGS (DNA Amplicon-seq, Exome) Microarray NGS (RNA Amplicon-seq)	WES Amplicon-seq (tumor) + WES (blood) Expression array RNA Amplicon-seq	Controlled-access (Type I)	2021-03-09

Data provider

Principal investigator: Ken Yamaguchi
Affiliation: Shizuoka Cancer Center

Research projects

Name	URL
Project HOPE (High-tech Omics-based Patient Evaluation) / Shizuoka Cancer Center	https://www.scchr.jp/en/institute/projecthope.html (opens in a new tab)

Grants

No grants.

Related publications

Title	DOI	Dataset ID
Implementation of individualized medicine for cancer patients by multiomics-based analyses-the Project HOPE-	https://doi.org/10.2220/biomedres.35.407 (opens in a new tab)	N/A
Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations	https://doi.org/10.1038/s41598-018-26967-4 (opens in a new tab)	JGAD000141
Integrated next-generation sequencing analysis of whole exome and 409 cancer-related genes	https://doi.org/10.2220/biomedres.37.367 (opens in a new tab)	N/A
Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors	https://doi.org/10.1038/s41598-017-00219-3 (opens in a new tab)	N/A
Next generation sequencing approach for detecting 491 fusion genes from human cancer	https://doi.org/10.2220/biomedres.37.51 (opens in a new tab)	N/A
Japanese version of The Cancer Genome Atlas, JCGA, established using fresh frozen tumors obtained from 5143 cancer patients	https://doi.org/10.1111/cas.14290 (opens in a new tab)	JGAD000380

Controlled access users

Principal investigator	Affiliation	Country/Region	Research title	Period of data use	Dataset ID
Masaki Mandai	department of Gynecology and Obstetrics, Kyoto University Faculty of Medicene	Japan	Integrated analyses of omics (genomics, transcriptomics, proteomics and metabolomics) associated with clinical variables for developing indivisualizedtreatment in gynecological malignancy	2018-10-04 – 2025-04-14	JGAD000141 JGAD000380
Koshi Mimori	Department of Surgery, Kyushu University Beppu Hospital	Japan	Transomic analysis of molecular characterization of Japanese breast cancer	2021-06-01 – 2025-08-05	JGAD000141 JGAD000380
Noriomi Matsumura	Obstetrics and Gynecology, Kindai University	Japan	Integrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR1	2024-10-15 – 2027-12-31	JGAD000141 JGAD000380 JGAD000733 JGAD000848
Ken Yamaguchi	Gynecology and Obstetrics, Kyoto University	Japan	Integrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR1	2024-10-22 – 2027-12-31	JGAD000848