Research ID
hum0127-v4Release info
Latest
Research title
Implementation of individualized medicine for cancer patients by multiomics-based analyses - the Project HOPE (High-tech Omics-based Patients Evaluation) for Cancer Therapy
Research overview
- Aims
- Blood and surgically removed tissues donated by approximately 1,000 cancer patients annually from Shizuoka Cancer Center's surgical cases are analyzed using multi-omics analysis technologies including genome, transcriptome, proteome, metabolome, and methylome. Tumor tissue analyses identified cancer driver genes and inherited cancer-causing genes in individual cancer patients and clarified the molecular profiling and sequential somatic mutation shift in hypermutator tumors harborig POLE mutations. Germline genome analysis will also be used to examine the presence or absence of hereditary cancers. Genetic polymorphisms of drug-metabolizing enzymes will be examined for associations with drug sensitivity and side effects. These results will be used to develop new drug discovery, diagnostics, and other treatment technologies.
- Methods
- DNAs and RNAs extracted from peripheral blood cells, tumor and non-tumor tissues are analyzed by whole-exome sequencing, DNA amplicon sequencing, RNA amplicon sequencing, microarray, Whole genome sequencing, and Methylation array.
- Participants/materials
- JGAS000130: 91 hypermutated solid tumors obtained from patients who had surgeries to remove cancers at the Shizuoka Cancer Center Hospital
JGAS000274: Fresh frozen tumors and blood cells obtained from 5143 cancer patients who had surgeries to remove cancers at the Shizuoka Cancer Center Hospital
JGAS000604: Gastrointestinal stromal tumor (GIST) 30 cases
JGAS000715: 177 cases in which no changes in driver genes were detected by whole exon sequencing and whole gene expression analysis in 5143 cancer patients who underwent surgery at Shizuoka Cancer Centre Hospital.
Datasets
| Cart | Dataset ID | Type of data | Analysis method | Access criteria | Date published |
|---|---|---|---|---|---|
| JGAD000141 | NGS (Exome) |
| Controlled-access (Type I) | 2020-09-28 | |
| JGAD000380 | NGS (Exome; somatic mutation) NGS (Exome; germline mutation) NGS (Exome; CNV) NGS (DNA Amplicon-seq, Exome) Microarray NGS (RNA Amplicon-seq) |
| Controlled-access (Type I) | 2021-03-09 | |
| JGAD000733 | NGS (WGS) Microarray (Gene expression profiling) Methylation array |
| Controlled-access (Type I) | 2024-01-24 | |
| JGAD000848 | NGS (WGS) |
| Controlled-access (Type I) | 2024-07-10 |
Data provider
- Principal investigator
- Ken Yamaguchi
- Affiliation
- Shizuoka Cancer Center
Research projects
| Name | URL |
|---|---|
Project HOPE (High-tech Omics-based Patient Evaluation) / Shizuoka Cancer Center |
Grants
No grants.
Related publications
| Title | DOI | Dataset ID |
|---|---|---|
Implementation of individualized medicine for cancer patients by multiomics-based analyses-the Project HOPE- | N/A | |
Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations | ||
Integrated next-generation sequencing analysis of whole exome and 409 cancer-related genes | N/A | |
Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors | N/A | |
Next generation sequencing approach for detecting 491 fusion genes from human cancer | N/A | |
Japanese version of The Cancer Genome Atlas, JCGA, established using fresh frozen tumors obtained from 5143 cancer patients | ||
Whole-genome and epigenomic landscapes of malignant gastrointestinal stromal tumors harboring KIT exon 11 557-558 deletion mutations |
Controlled access users
| Principal investigator | Affiliation | Country/Region | Research title | Period of data use | Dataset ID |
|---|---|---|---|---|---|
| Masaki Mandai | department of Gynecology and Obstetrics, Kyoto University Faculty of Medicene | Japan | Integrated analyses of omics (genomics, transcriptomics, proteomics and metabolomics) associated with clinical variables for developing indivisualizedtreatment in gynecological malignancy | 2018-10-04 – 2025-04-14 | |
| Koshi Mimori | Department of Surgery, Kyushu University Beppu Hospital | Japan | Transomic analysis of molecular characterization of Japanese breast cancer | 2021-06-01 – 2025-08-05 | |
| Noriomi Matsumura | Obstetrics and Gynecology, Kindai University | Japan | Integrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR1 | 2024-10-15 – 2027-12-31 | |
| Ken Yamaguchi | Gynecology and Obstetrics, Kyoto University | Japan | Integrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR1 | 2024-10-22 – 2027-12-31 |