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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0127-v1Release info

This page is a past version (v1). The latest version is v4.
Latest version (v4)

Research title

Implementation of individualized medicine for cancer patients by multiomics-based analyses - the Project HOPE (High-tech Omics-based Patients Evaluation) for Cancer Therapy

Research overview

Aims
To clarify molecular biological features and develop new cancer treatments by searching for mutations in the POLE gene region in tumor tissues and the ones frequently present in genes involved in the development and progression of cancers
Methods
DNAs extracted from peripheral blood cells (non-tumor tissues) and tumor tissues are analyzed by whole-exome sequencing
Participants/materials
91 hypermutated solid tumors that obtained from patients who take surgeries to remove tumor tissues at the Shizuoka Cancer Center Hospital
URL

Datasets

The list is the one this version published; each dataset's content is shown as it is now.

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000141NGS (Exome)
  • WES
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Ken Yamaguchi
Affiliation
Shizuoka Cancer Center

Research projects

NameURL
Project HOPE (High-tech Omics-based Patient Evaluation) / Shizuoka Cancer Center

Grants

No grants.

Related publications

TitleDOIDataset ID
Implementation of individualized medicine for cancer patients by multiomics-based analyses-the Project HOPE-
https://doi.org/10.2220/biomedres.35.407 (opens in a new tab)
N/A
Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations
https://doi.org/10.1038/s41598-018-26967-4 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Masaki Mandaidepartment of Gynecology and Obstetrics, Kyoto University Faculty of MediceneJapanIntegrated analyses of omics (genomics, transcriptomics, proteomics and metabolomics) associated with clinical variables for developing indivisualizedtreatment in gynecological malignancy2018-10-04 – 2025-04-14
Koshi MimoriDepartment of Surgery, Kyushu University Beppu HospitalJapanTransomic analysis of molecular characterization of Japanese breast cancer2021-06-01 – 2025-08-05
Noriomi MatsumuraObstetrics and Gynecology, Kindai UniversityJapanIntegrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR12024-10-15 – 2027-12-31
Ken YamaguchiGynecology and Obstetrics, Kyoto UniversityJapanIntegrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR12024-10-22 – 2027-12-31