Research ID
hum0120-v4Release info
Research title
The genetic analysis of circulating tumor DNA in blood of the digestive cancer patients to investigate the prognostic factors of metastasis and reccurence.
Research overview
- Aims
- To identify the biomarkers of predicting metastasis and recurrence in colorectal cancer (CRC), gastric cancer, and breast cancer.
- Methods
- - DNAs and RNAs were extracted from the tumor and matched normal tissues. Whole exome sequencing was performed using tumor and matched normal tissues. RNA-seq, TCR repertoire, methylation array, and whole genome bisulfite sequencing analyses were performed using tumor tissues.
- Circulating tumor DNA were extracted from patients plasma and targeted sequence were performed. - Participants/materials
- 10 cases of stage 1 and 2 CRCs, which cases occurred liver or lung metastasis.
- URL
- N/A
Datasets
| Cart | Dataset ID | Type of data | Analysis method | Access criteria | Date published |
|---|---|---|---|---|---|
| JGAD000311 | NGS (Exome) |
| Controlled-access (Type I) | 2020-09-28 | |
| DRA011183 | NGS (Exome) |
| Unrestricted-access | 2020-12-14 | |
| DRA011184 | NGS (RNA-seq) |
| Unrestricted-access | 2020-12-14 | |
| DRA011185 | NGS (Target Capture) |
| Unrestricted-access | 2020-12-14 | |
| JGAD000667 | NGS (Target Capture) |
| Controlled-access (Type I) | 2022-07-24 | |
| E-GEAD-396 | Methylation array |
| Unrestricted-access | 2021-12-08 | |
| DRA010902 | NGS (WGBS) |
| Unrestricted-access | 2021-12-08 |
Data provider
- Principal investigator
- Koshi Mimori
- Affiliation
- Department of Surgery, Kyushu University Beppu Hospital
Research projects
No research projects.
Grants
| Name | Title | Project number |
|---|---|---|
Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED) | Understanding of molecular mechanisms to generate genetic heterogeneity associated with micro-environmental diversity for development of novel therapy and diagnostic technology in intractable cancers. |
|
Related publications
| Title | DOI | Dataset ID |
|---|---|---|
Pan-cancer methylome analysis for cancer diagnosis and classification of cancer cell of origin. |
Controlled access users
| Principal investigator | Affiliation | Country/Region | Research title | Period of data use | Dataset ID |
|---|---|---|---|---|---|
| Kouya Shiraishi | Division of Genome Biology, National Cancer Research Institute | Japan | Elucidation of immune-system networks between host and tumor based on genomic analysis | 2019-08-05 – 2029-03-31 |
|