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NBDC Research ID:hum0096-v1
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Title

Comprehensive analysis of genetic alterations in hematological malignancies

Research overview

Aims: To explore genetic alteratoins in pediatric T-cell acute lymphoblastic leukemia (T-ALL), we performed genome wide analysis using next generation sequencing methods.

Methods: We performed whole transcriptome sequencing in 123 pediatric T-ALL for detecting gene fusion and analysing expression data. Among them, 79 cases were further analyzed in DNA metylation array.

Targets: 123 pediatric T-ALL patients

Datasets

Dataset ID
Access type
Type of data
Release date
JGAD000090Controlled-access (Type I)NGS (RNA-seq)2020-09-28

Data provider

    Principal Investigator
    Junko Takita
    Affiliation
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo

Research projects

Name
URL
No data

Grants

Name
Title
Project number
Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)Development for novel therapeutic stratagies of intractable cancers in children and adolescent and young adult using molecular profilings
  • JP16cm0106509
KAKENHI Grant-in-Aid for Scientific Research (B)Development for novel therapeutic stratagies of intractable pediatric cancers based on the multi-omics analysis
  • 17H04224

Related publications

Title
DOI
Datasets
Recurrent PU.1 (SPI1) fusions in high-risk pediatric T cell acute lymphoblastic leukemiahttps://doi.org/10.1038/ng.3900
DNA methylation-based classification reveals difference between pediatric T-cell acute lymphoblastic leukemia and normal thymocyteshttps://doi.org/10.1038/s41375-019-0626-2

Controlled access users

Principal Investigator
Affiliation
Country/Region
Research title
Period of data use
Data in use (Dataset ID)
de Bock CharlesUniversity of New South WalesUnited KingdomElucidating the role of the TCF7-SPI1 fusion in T cell acute lymphoblastic leukemia2020-08-17—2021-08-18
Mullighan CharlesSt. Jude Children's Research HospitalUSAGenomic analysis of acute lymphoblastic leukemia2019-10-11—2024-12-05
Sanda TakaomiNagoya City University Graduate School of Medical SciencesJapanSequencing and Expression Analyses in T-Cell Leukemia Using Publicly-Available Datasets2020-07-14—2024-09-30
Hamada MichiakiWaseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05—2027-10-31
Huang JinyanZhejiang UniversityChinaComprehensive analysis of alternative splicing in malignant tumors2022-03-15—2024-01-02
Huang JinyanRui-jin HospitalChinaComparing analysis adult and Pediatric B-cell Acute Lymphoblastic Leukemia2017-07-19—2023-07-13
Yang JunSt. Jude Children's Research HospitalUSAGENOMICS OF ANTILEUKEMIC DRUG SENSITIVITY IN ALL2019-04-11—2022-01-26
Bernard OlivierInstitut Gustave RoussyFranceNormal and malignant hematopoiesis (Hématopoiese normale et pathologique)2017-09-14—2021-03-19
Yasuda TakahikoNagoya Medical CenterJapanBasic research aimed at elucidating the molecular pathology and developing effective and safe treatment methods for hematological diseases2022-01-13—2030-03-31
Liang ChengyuThe Wistar InstituteUSAOncogenic mechanism of T-cell lymphoblastic leukemia2022-01-14—2027-11-22