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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0096-v1Release info

This page is a past version (v1). The latest version is v2.
Latest version (v2)

Research title

Comprehensive analysis of genetic alterations in hematological malignancies

Research overview

Aims
To explore genetic alteratoins in pediatric T-cell acute lymphoblastic leukemia (T-ALL), we performed genome wide analysis using next generation sequencing methods.
Methods
We performed whole transcriptome sequencing in 123 pediatric T-ALL for detecting gene fusion and analysing expression data. Among them, 79 cases were further analyzed in DNA metylation array.
Participants/materials
123 pediatric T-ALL patients
URL
N/A

Datasets

The list is the one this version published; each dataset's content is shown as it is now.

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000090NGS (RNA-seq)
  • RNA-seq
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Junko Takita
Affiliation
Department of Pediatrics, Graduate School of Medicine, The University of Tokyo

Research projects

No research projects.

Grants

NameTitleProject number
Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)
Development for novel therapeutic stratagies of intractable cancers in children and adolescent and young adult using molecular profilings
  • JP16cm0106509
KAKENHI Grant-in-Aid for Scientific Research (B)
Development for novel therapeutic stratagies of intractable pediatric cancers based on the multi-omics analysis
  • 17H04224

Related publications

TitleDOIDataset ID
Recurrent PU.1 (SPI1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia
https://doi.org/10.1038/ng.3900 (opens in a new tab)
DNA methylation-based classification reveals difference between pediatric T-cell acute lymphoblastic leukemia and normal thymocytes
https://doi.org/10.1038/s41375-019-0626-2 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Jinyan HuangState Key Laboratory Of Medical Genomics, Rui-jin HospitalChinaComparing analysis adult and Pediatric B-cell Acute Lymphoblastic Leukemia2017-07-19 – 2023-07-13
Olivier BERNARDInstitut Gustave RoussyFranceNormal and malignant hematopoiesis (Hématopoiese normale et pathologique)2017-09-14 – 2021-03-19
Jun YangDepartment of Pharmaceutical Science, St. Jude Children's Research HospitalTennessee, United StatesGENOMICS OF ANTILEUKEMIC DRUG SENSITIVITY IN ALL2019-04-11 – 2022-01-26
Charles MullighanPathology Department, St. Jude Children's Research HospitalTennessee, United StatesGenomic analysis of acute lymphoblastic leukemia2019-10-11 – 2024-12-05
Takaomi SandaCancer Science Institute of Singapore, National University of SingaSingaporeSequencing and Expression Analyses in T-Cell Leukemia Using Publicly-Available Datasets2020-07-14 – 2024-09-30
Charles de BockChildren's Cancer Institute, University of New South WalesNew South Wales, AustraliaElucidating the role of the TCF7-SPI1 fusion in T cell acute lymphoblastic leukemia2020-08-17 – 2021-08-18
Jinyan HuangZhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China. Biomedical big data center, the First Affiliated Hospital, Zhejiang UniversityChinaComprehensive analysis of alternative splicing in malignant tumors2022-03-15 – 2024-01-01
Chengyu LiangThe Wistar institutePennsylvania, United StatesOncogenic mechanism of T-cell lymphoblastic leukemia2022-01-14 – 2027-11-22
Takahiko YasudaClinical Researc Center, Nagoya Medical CenterJapanBasic research aimed at elucidating the molecular pathology and developing effective and safe treatment methods for hematological diseases2022-01-13 – 2030-03-31
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31