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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0055-v1Release info

Latest

Research title

Genetic and epigentic analysis of non-alcoholic fatty liver disease

Research overview

Aims
To elucidate the mRNA expression related to the development and/or progression of non-alcoholic fatty liver disease (NAFLD).
Methods
RNA-seq and Methylation array analysis by using of mRNA or DNA purified from liver tissues
Participants/materials
64 NAFLD patients
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000059NGS (RNA-seq)
Methylation array
  • RNA-seq
  • メチル化アレイ
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Kikuko Hotta
Affiliation
Department of Medical Innovation, Osaka University Hospital

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (C)
Genetic predisposition and environmental factor retrieval of ectopic fat accumulation and their verification in prospective follow-up survey
  • 25461343
KAKENHI Grant-in-Aid for Scientific Research (C)
Elucidation of pathology and development of diagnosis method of nonalcoholic fatty liver disease by using genomic, and epigenomic analysis
  • 16K09781
KAKENHI Grant-in-Aid for Scientific Research (C)
Analysis of genetic predisposition and environmental factors related to the onset and progression of nonalcoholic fatty liver disease
  • 26460999

Related publications

TitleDOIDataset ID
Identification of core gene networks and hub genes associated with progression of nonalcoholic fatty liver disease by RNA sequencing
https://doi.org/10.1111/hepr.12877 (opens in a new tab)
Identification of the genomic region under epigenetic regulation during nonalcoholic fatty liver disease progression.
https://doi.org/10.1111/hepr.12992 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Pablo GiraudiFondazione Italiana Fegato (ONLUS)ItalyMeta-analysis of omics data on non-alcoholic fatty liver disease. Implications for the improvement of an in silico strategy for biomarkers discovery on liver fibrosis2018-12-18 – 2021-02-08
Masanori NojimaThe Institute of Medical Science, The University of TokyoJapanGenome-wide DNA methylation analysis for the development of prediction model for subsequent hepato-cellular carcinoma in non-alcoholic fatty liver disease patients2019-01-21 – 2022-03-28
Robert TsaiInstitute of Biosciences & Technology, Texas A&M Health Science CenterTexas, United StatesGenome-wide Discovery of new Plasma DNA Methylation Markers for Tracking the Progression of NAFLD to NASH and HCC2020-11-09 – 2023-07-25
Kikuko HottaLaboratory of Pathophysiology and Pharmacotherapeutics Faculty of Pharmacy, Osaka Ohtani UniversityJapanGenomic and epigenomic analysis of liver disease (nonalcoholic fatty liver disease, virus hepatitis, alcoholic hepatitis, cirrhosis, and hepatocellular carcinoma) 2021-11-11 – 2023-04-05
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31