Research ID
hum0043-v1Release info
Latest
Research title
Japanese Alzheimer's disease neuroimaging initiative (J-ADNI)
Research overview
- Aims
- Japanese ADNI aims to establish imaging and biofluid markers that can predict and monitor the progression of changes in the brains of elderly individuals with AD, mild cognitive impairment (MCI) or normal cognition, and eventually be used as a surrogate markers for the clinical trials of DMDs for AD.
- Methods
- The research protocol includes structural MRI analysis, FDG and amyloid PET, CSF sampling, apoE genotyping, combined with a set of clinical and psychometric tests that were prepared to achieve the highest compatibility to those used in US-ADNI.
- Participants/materials
- Participants enrolled in a longitudinal study: 537 (healthly elderly controls: 154, mild cognitive impairment (MCI): 234, Alzheimer's disease (AD): 149)
- URL
- N/A
Datasets
| Cart | Dataset ID | Type of data | Analysis method | Access criteria | Date published |
|---|---|---|---|---|---|
| JGAD000051 | Brain MRI, PET (FDG, PIB, BF227), clinical/psychometric tests, and biochemical assays collected in the J-ADNI trial. Includes ADAS, CDR, MMSE cognitive assessments, ApoE genotype, CSF, and peripheral blood tests. |
| Controlled-access (Type I) | 2020-09-28 |
Data provider
- Principal investigator
- Takeshi Iwatsubo
- Affiliation
- Department of Neuropathology, Graduate School of Medicine, the University of Tokyo
Research projects
| Name | URL |
|---|---|
Japanese Alzheimer's disease neuroimaging initiative (J-ADNI) (List of Authors, Citation Information) | N/A |
Grants
| Name | Title | Project number |
|---|---|---|
New Energy and Industrial Technology Development Organization of Japan (NEDO) Translational Research Promotion Project | Research Project for the Development of a Systematic Method for the Assessment of Alzheimer's Disease |
|
Health Labour Sciences Research Grant Research on Dementia | Multisite longitudinal study for the evaluation of clinical manifestation and progression of Alzheimer disease: J-ADNI core study |
|
Health Labour Sciences Research Grant Research on Dementia | J-ADNI core study: analysis and application of imaging biomarkers and establishment of clinical study network |
|
Life Science Database Integration Project (Database Integration Coordination Program) of Japan Science and Technology Agency | Study on integration of the human brain related diseases imaging data | N/A |
Related publications
| Title | DOI | Dataset ID |
|---|---|---|
Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials. |
Controlled access users
| Principal investigator | Affiliation | Country/Region | Research title | Period of data use | Dataset ID |
|---|---|---|---|---|---|
| Michael Donohue | Alzheimers Therapeutic Research Institute, University of Southern California | California, United States | Long-term disease trajectories and clinical trial design and analysis | 2016-03-30 – 2021-03-26 | |
| Ryuichi Takahashi | Department of Neurology, Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima | Japan | Search for ApoE4 effects on amyloid deposition and gray matter atrophy by using of PiB-positive MCI | 2016-04-27 – 2018-09-06 | |
| Kenji Ishii | Neuroimaging Research Team, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology | Japan | Analysis of J-ADNI PET data using NBDC human database. | 2016-05-02 – 2021-03-19 | |
| Hiroshi Matsuda | Integrative Brain Imaging Center, National Center of Neurology and Psychiatry | Japan | Study on neuroimaging using open files from Japanese Alzheimer's disease neuroimaging initiative | 2016-06-01 – 2021-03-01 | |
| Weining Robieson | Data and Statistical Sciences, AbbVie | Illinois, United States | Evaluation of longitudinal changes in clinical assessments and biomarkers for subjects with mild cognitive impairment (MCI), Alzheimer's Disease (AD) and normalcontrols using Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) data | 2016-08-05 – 2022-07-19 | |
| Michio Senda | Division of Molecular Imaging, Institute of Biomedical Research and Innovation | Japan | Evaluation of imaging biomarkers for dementia based on the J-ADNI dataset | 2016-08-05 – 2021-02-10 | |
| Takashi Kato | Department of Radiology, National Center for Geriatrics and Gerontology | Japan | Analyses of the J-ADNI data | 2016-10-14 – 2027-03-31 | |
| Ken Aoshima | hhc Data Creation Center, Eisai Co., Ltd. | Japan | Comprehensive AD biomaker and disease modifying drug development related analysis by using J-ADNI data | 2016-09-23 – 2027-03-31 | |
| Masashi Kikuchi | Development Clinical Research Neuroscience Group, MSD K.K. Japan | Japan | Study to investigate disease progression in Japanese mild cognitive impairment and Alzheimer's disease patients | 2016-10-12 – 2021-03-18 | |
| Hiroshi Suzuki | Department of Pharmacy, The University of Tokyo Hospital | Japan | An Analysis of The Progression of Alzheimer's Disease in The Japanese Population by Using J-ADNI Data | 2017-01-11 – 2025-09-02 | |
| Masayasu Okochi | Department of Psychiatry, Osaka University Graduate School of Medicine | Japan | Utilization of Data obtained by J-ADNI research for the purpose of development of blood-based Alzheimer's disease biomarker | 2017-02-02 – 2021-12-20 | |
| Joyce Suhy | Bioclinica, Inc. | California, United States | vMRI validation on Toshiba Scanners using J-ADNI data | 2017-04-04 – 2019-02-07 | |
| Toshiharu Suzuki | Faculty of Pharmaceutical Sciences, Hokkaido University | Japan | NBDC Human Database use for analysis of p3-Alc peptides, the blood biomarker for Alzheimer's disease | 2017-05-02 – 2024-11-15 | |
| Danielle Harvey | Division of Biostatistics, UC Davis | California, United States | Comparison of Japan-ADNI and North America ADNI | 2017-05-02 – 2021-03-26 | |
| Jae-Won Jang | Department of Neurology, Kangwon National University Hospital | South Korea | COMPREHESIVE VISURAL RATING SCALE ON MRI: APPLICATION TO ALZHEIMER’S DISEASE, MILD COGNITIVE IMPAIRMENT AND SUBJECTIVE MEMORY IMPAIRMENT | 2017-05-02 – 2021-01-23 | |
| Masayuki Sasaki | Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University | Japan | Study of imaging biomarkers for dementia based on the clinical research database | 2017-06-21 – 2022-03-03 | |
| Akihiko Shiino | Molecular Neuroscience Research Center, Shiga University of Medical Science | Japan | Neuroimage diagnosis of dementia using J-ADNI database | 2017-06-30 – 2018-08-08 | |
| Kiyoto Kasai | Department of Neuropsychiatry, the University of Tokyo Hospital | Japan | Construction of a database comprising brain images acquired with magnetic resonance imaging and clinical evaluation scales and its multi-centered collaborative operation | 2017-07-19 – 2021-02-02 | |
| Yuanzhong Li | Imaging Technology Center, FUJIFILM Corpration | Japan | Acquisition of data for evaluation of dementia diagnosis | 2017-09-05 – 2024-09-06 | |
| Atsushi Iwata | Department of Neurology, The University of Tokyo Hospital | Japan | Comprehensice epigenome analysis of J-ADNI peripheal blood samples | 2017-09-14 – 2021-08-19 | |
| Tosimasa Yamamoto | Neurology, Saitama Medical University | Japan | Evaluation of a method for objectively evaluating brain image change using brain image analysis software in degenerative diseases including Parkinson's syndrome and Alzheimer type dementia. | 2017-09-14 – 2023-06-30 | |
| Kazushi Suzuki | Unit for early and exploratory development, The University of Tokyo Hospital | Japan | A study on predictors for progression of Alzheimer disease using large-scale longitudial cohort study of Japan, USA, and Australia | 2017-10-11 – 2021-03-17 | |
| TSUKASA FUNANE | Research & Development Group, Center for Exploratory Research, Hitachi, Ltd. | Japan | Research on changes in clinical condition and diagnostic marker in Alzheimer's disease (AD) patients, mild cognitive impairment (MCI) patients, and healthy control (HC) people using Alzheimer's disease clinical databases that are collected and opened by domestic and international organizations | 2017-12-11 – 2021-01-25 | |
| Tadanori Fukami | Graduate school of science and engineering, Yamagata University | Japan | Longitudinal analysis for J-ADNI database by MRI/PET image fusion | 2017-12-26 – 2021-01-22 | |
| Shuhei Yamaguchi | Department of Internal Medicine III, Shimane University | Japan | Development of diagnosis support program using machine learning for brain MRI | 2018-01-09 – 2035-03-31 | |
| Manabu ISHIDA | ERISA Co., Ltd. | Japan | Development of diagnosis support program using machine learning for brain MRI | 2018-01-09 – 2025-03-31 | |
| Tetsutaro Ono | Communication & Information Center / Information Innovation Operations, Dai Nippon Printing Co., Ltd. | Japan | Study on morphological change due to aging of the brain and early diagnosis support of Alzheimer type dementia using recorded MR image data. | 2018-04-20 – 2027-03-31 | |
| Sayuri Watanabe | R&D, Clinical science division, Janssen pharmaceutical K.K | Japan | Analysis of J-ADNI data | 2018-06-07 – 2026-09-07 | |
| Eric Westman | NVS Department, Division of Clinical Geriatrics, Karolinska Institutet | Sweden | Heterogeneity within pre-dementia stages of Alzheimer’s disease | 2018-09-11 – 2031-11-30 | |
| Nancy Maserejian | Safety and Benefit Risk Management, Global Development, Biogen | Massachusetts, United States | Natural history of MCI and AD | 2018-10-04 – 2026-12-31 | |
| Masataka KIKUCHI | Department of Genome Informatics, Graduate School of Medicine, Osaka University | Japan | Omics research for dementia based on clinical and genome data | 2019-01-21 – 2022-10-03 | |
| Christian Núñez | Research Unit, Parc Sanitari Sant Joan de Déu | Spain | Gray matter volumetry and cortical thickness as biomarkers of psychiatric and neurologic disease severity | 2019-03-13 – 2021-03-26 | |
| Naoki Tomita | Geriatric medicine and neuroimaging, Tohoku university hospital | Japan | Investigations on common geriatric problems using international database of Alzheimer's disease | 2019-06-06 – 2024-11-12 | |
| Akinori Miyashita | Department of Molecular Genetics, Brain Research Institute, Niigata University | Japan | Study on dementia with large-scare omics data | 2020-06-04 – 2028-01-23 | |
| Akira Suda | Yokohama City University Hospital | Japan | Retrospective investigation on relationship between immunological biomarkers and clinical findings of Alzheimer's disease | 2020-01-09 – 2023-02-06 | |
| Martin Hofmann-Apitius | Department forBioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing SCAI | Germany | The Virtual Brain - Cloud (Personalized Recommendations for Neurodegenerative Disease) | 2020-03-11 – 2025-01-22 | |
| Hisatomo Kowa | Division of Cognitive and Psychiatric Rehabilitation, Dept of Rehabilitation Science, Kobe University Graduate School of Health Sciences | Japan | Optimizing Evaluation Method for Cognitive Function of Aged People Based on the J-ADNI Database | 2020-01-15 – 2023-07-10 | |
| Colin Masters | AIBL, The Florey Institute, The University of Melbourne | Victoria, Australia | The Australian Imaging and Biomarker Study (AIBL) Flagship Study of Ageing | 2020-09-22 – 2025-09-30 | |
| Pieter Visser | Department of Psychiatry and Neuropsychology, Maastricht University | Netherlands | Amyloid Biomarker Study | 2020-11-09 – 2024-05-01 | |
| Akihiro Hirakawa | 医学部附属病院 臨床試験管理センター 生物統計学・データサイエンス部, 東京医科歯科大学 | Japan | Development and validation of disease progression prediction model in Alzheimer’s disease using cognitive assessment data | 2020-12-04 – 2028-03-31 | |
| Masahiko Takemura | Open Health Initiative, Open Health Initiative | Japan | Developing and validating models that predict cognitive decline | 2021-05-14 – 2023-03-30 | |
| Jason Bock | Informatics, Embic | California, United States | Developing Hierarchical Bayesian Cognitive Processing Models for Description, Group Differentiation, and Prediction with Wordlist Memory Test | 2021-05-25 – 2025-06-06 | |
| Hieab Adams | Clinical Genetics, Erasmus MC | Netherlands | Uncovering Neurodegenerative Insights Through Ethnic Diversity | 2021-04-28 – 2024-04-11 | |
| Tadanori Fukami | Graduate school of science and engineering, Yamagata University | Japan | Longitudinal analysis for J-ADNI database by MRI/PET image fusion | 2021-06-24 – 2026-03-02 | |
| Kazushi Suzuki | Department of Neurology, National Defense Medical College | Japan | Natural history study of neurodegenerative diseases using clinical research data | 2021-08-11 – 2031-03-31 | |
| Hiroki Masuda | Department of Neurology, Graduate School of Medicine, Chiba University | Japan | Analysis of the longitudinal brain atrophy and cognitive function in patients with multiple sclesosis and neuromyelitis optica spectrum disorder. | 2021-11-30 – 2027-03-31 | |
| Yoon Seong Choi | Diagnostic Radiology, Yonsei University College of Medicine | South Korea | A deep learning model for Alzheimer disease based on 18F-FDG=PET: prognostication of mild cognitive impairment | 2021-12-24 – 2025-06-26 | |
| Kaoru Sakatani | AICOG Labo, Iko Health Technologies | Japan | Study on the risk prediction of dementia by analyzing the Human Database: J-ADNI | 2022-02-25 – 2022-09-01 | |
| Qian Gao | Cytox Ltd | United Kingdom | Proposed project title: Evaluation of the performance of genoSCORE for predicting onset of Alzheimer’s disease in a Japanese population; Required data access from NBDC: Japanese Alzheimer's disease neuroimaging initiative (J-ADNI); Data provider: Dr Takeshi Iwatsubo, The University of Tokyo | 2022-03-15 – 2023-12-31 | |
| Tatsuya Ando | Neuroscience Computational Biology, Research, Takeda Pharmaceutical Company Limited | Japan | Development of machine learning prediction model for detecting neurodegenerative diseases using J-ADNI human brain image data | 2022-09-21 – 2027-05-31 | |
| Christian Wachinger | Artificial Intelligence in Radiology Department of Radiology, Technical University of Munich | Germany | Replication of neural network predictions on independent test data | 2022-03-28 – 2026-12-31 | |
| TING-WEI WENG | Translational Imaging Research Center, Taipei Medical University | Taiwan | Building a national model of data hub for healthy aging | 2022-05-24 – 2024-06-17 | |
| Sandra Black | LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute | Ontario, Canada | Comparative study on the longitudinal changes in cerebral small vessel disease between Japanese and Western country populations | 2022-07-13 – 2027-05-31 | |
| Fan Yi | College of Computer Science and Technology, Zhejiang University | China | Research on the analysis method of chronic disease evolution process based on data mining of electronic medical records | 2022-11-25 – 2023-12-31 | |
| Masataka Kikuchi | Department of Computational Biology and Medical Sciences, The University of Tokyo | Japan | Omics research for dementia based on clinical and genome data | 2022-10-03 – 2025-10-16 | |
| Chengan Guo | School of Information and Communication Engineering, Dalian University of Technology | China | Research on early diagnoses for Alzheimer's disease and mild cognitive impairment based on deep learning | 2023-06-13 – 2025-08-31 | |
| Yasuda Mikihiro | 理工学研究科 作元研究室, 関西学院大学 | Japan | Construction of a method for analyzing brain networks based on fMRI data | 2023-08-25 – 2025-01-23 | |
| Mongkol Ekpanyapong | AI Center AI Center, Asian Institute of Technology(AIT) | Thailand | Technical, clinical validation and diagnostic accuracy of artificial intelligence (AI) based quantitative structural MRI application for dementia diagnosis in Thai population. | 2024-01-25 – 2025-07-31 | |
| Sreevani Katabathula | Center for Artificial intelligence in Drug Discovery, Case Western Reserve University | Ohio, United States | Subtype Analysis in Mild cognitive impairment of Alzheimer’s disease | 2023-08-09 – 2024-08-01 | |
| SHAHRUM SHAH ABDULLAH | Malaysia Japan International Institute of Technology, Unversiti Teknologi Malaysia | Malaysia | Diagnosing Alzheimer’s Disease in a Japanese Population Using Deep Learning Approach | 2023-12-28 – 2024-12-13 | |
| Rachel Buckley | Neurology, Massachusetts General Hospital | United States | Building predictive algorithms to identify resilience and resistance to Alzheimer’s disease | 2024-02-14 – 2028-02-25 | |
| Dittapong Songsaeng | Department of Radiology, Siriraj Hospital | Thailand | Technical, clinical validation and diagnostic accuracy of artificial intelligence (AI) based quantitative structural MRI application for dementia diagnosis in Thai population. | 2024-01-25 – 2024-07-09 | |
| Katsumi Aoyagi | Research and development, FUJIREBIO INC. | Japan | Diagnostic Potential of Dementia Biomarkers in Japanese Clinical Cases. | 2024-09-03 – 2025-08-26 | |
| Yasuyuki Taki | Aging Research and Geriatric Medicine, Tohoku University Institute of Development, Aging and Cancer | Japan | Verification of the effects of moderate-intensity exercise using IoT devices on general clinical symptoms and cognitive function, with a comparison to existing cohort data | 2025-01-27 – 2027-03-31 | |
| Ryosuke Shimasaki | Tokyo Metropolitan Institute for Geriatrics and Gerontology | Japan | Characteristics of Lecanemab Treatment Candidates Using J-ADNI Data | 2025-09-18 – 2027-12-31 | |
| Bin Zhou | Department of Global Alliance, Foundation of Learning Health Society Institute | Japan | Cross-validation for Predicting the onset time of Alzheimer’s Disease using J-ADNI data | 2025-10-20 – 2026-09-30 | |
| Kenichiro Sato | The University of Tokyo Hospital | Japan | Data analysis research regarding social implementation of novel Alzheimer's disease treatment | 2025-12-01 – 2030-03-31 | |
| Yoshitsugu Nakamura | Osaka Medical and Pharmaceutical University | Japan | An Investigation of Factors Associated with the Therapeutic Efficacy of Anti-Amyloid-β Antibody Drugs for Alzheimer's Disease | 2026-08-18 – 2027-07-16 | |
| TAKASHI KASAI | Neurology, Kyoto Prefectural University of Medicine | Japan | Research on molecular pathogenesis and development of treatments and preventive strategies for dementia. | 2026-09-24 – 2029-03-31 |