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NBDC Research ID:hum0043-v1
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Research title

Japanese Alzheimer's disease neuroimaging initiative (J-ADNI)

Research overview

Aims: Japanese ADNI aims to establish imaging and biofluid markers that can predict and monitor the progression of changes in the brains of elderly individuals with AD, mild cognitive impairment (MCI) or normal cognition, and eventually be used as a surrogate markers for the clinical trials of DMDs for AD.

Methods: The research protocol includes structural MRI analysis, FDG and amyloid PET, CSF sampling, apoE genotyping, combined with a set of clinical and psychometric tests that were prepared to achieve the highest compatibility to those used in US-ADNI.

Targets: Participants enrolled in a longitudinal study: 537 (healthly elderly controls: 154, mild cognitive impairment (MCI): 234, Alzheimer's disease (AD): 149)

Datasets

Dataset ID
Access type
Type of data
Release date
JGAD000051Controlled-access (Type I)Brain MRI, PET (FDG, PIB, BF227), clinical/psychometric tests, and biochemical assays collected in the J-ADNI trial. Includes ADAS, CDR, MMSE cognitive assessments, ApoE genotype, CSF, and peripheral blood tests.2016-01-29

Data provider

    Principal investigator
    Takeshi Iwatsubo
    Name
    Department of Neuropathology, Graduate School of Medicine, the University of Tokyo

Research projects

Name
URL
Japanese Alzheimer's disease neuroimaging initiative (J-ADNI) ([List of Authors](/en/hum0043-j-adni-authors), [Citation Information](https://www.neuropathology.m.u-tokyo.ac.jp/image/paper/J-ADNI-Citations.pdf))

Grants

Name
Title
Project number
New Energy and Industrial Technology Development Organization of Japan (NEDO) Translational Research Promotion ProjectResearch Project for the Development of a Systematic Method for the Assessment of Alzheimer's Disease
  • 20100000001577
Health Labour Sciences Research Grant Research on DementiaMultisite longitudinal study for the evaluation of clinical manifestation and progression of Alzheimer disease: J-ADNI core study
  • H19-認知症-指定-024
Health Labour Sciences Research Grant Research on DementiaJ-ADNI core study: analysis and application of imaging biomarkers and establishment of clinical study network
  • H22-認知症-指定-009
Life Science Database Integration Project (Database Integration Coordination Program) of Japan Science and Technology AgencyStudy on integration of the human brain related diseases imaging data

    Related publications

    Title
    DOI
    		Dataset ID
    Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials.https://doi.org/10.1016/j.jalz.2018.03.009

    Controlled access users

    Principal Investigator
    Affiliation
    Country/Region
    Research title
    Period of data use
    		Dataset ID
    Nakamura YoshitsuguOsaka Medical and Pharmaceutical UniversityJapanAn Investigation of Factors Associated with the Therapeutic Efficacy of Anti-Amyloid-β Antibody Drugs for Alzheimer's Disease2026-08-18—2027-07-16
    Iwata AtsushiTokyo Metropolitan Geriatric HospitalJapanComprehensice epigenome analysis of J-ADNI peripheal blood samples2017-09-14—2021-08-19
    Taki YasuyukiTohoku University Institute of Development, Aging and CancerJapanVerification of the effects of moderate-intensity exercise using IoT devices on general clinical symptoms and cognitive function, with a comparison to existing cohort data2025-01-27—2027-03-31
    Zhou BinFoundation of Learning Health Society InstituteJapanCross-validation for Predicting the onset time of Alzheimer’s Disease using J-ADNI data2025-10-20—2026-09-30
    Masters ColinThe University of MelbourneAustraliaThe Australian Imaging and Biomarker Study (AIBL) Flagship Study of Ageing2020-09-22—2025-10-01
    Nunez ChristianParc Sanitari Sant Joan de DeuSpainGray matter volumetry and cortical thickness as biomarkers of psychiatric and neurologic disease severity2019-03-13—2021-03-26
    Guo ChenganDalian University of TechnologyChinaResearch on early diagnoses for Alzheimer's disease and mild cognitive impairment based on deep learning2023-06-13—2025-09-01
    Ando TatsuyaTakeda Pharmaceutical Company LimitedJapanDevelopment of machine learning prediction model for detecting neurodegenerative diseases using J-ADNI human brain image data2022-09-21—2027-05-31
    Choi Yoon SeongYonsei University College of MedicineSouth KoreaA deep learning model for Alzheimer disease based on 18F-FDG=PET: prognostication of mild cognitive impairment2021-12-24—2025-06-26
    Gao QianCytox LtdUnited KingdomProposed project title: Evaluation of the performance of genoSCORE for predicting onset of Alzheimer’s disease in a Japanese population; Required data access from NBDC: Japanese Alzheimer's disease neuroimaging initiative (J-ADNI); Data provider: Dr Takeshi Iwatsubo, The University of Tokyo2022-03-15—2024-01-01
    Harvey DanielleUC DavisUSAComparison of Japan-ADNI and North America ADNI2017-05-02—2021-03-26
    Songsaeng DittapongSiriraj HospitalThailandTechnical, clinical validation and diagnostic accuracy of artificial intelligence (AI) based quantitative structural MRI application for dementia diagnosis in Thai population.2024-01-25—2024-07-10
    Westman EricKarolinska InstitutetSwedenHeterogeneity within pre-dementia stages of Alzheimer’s disease2018-09-11—2031-11-30
    Fukami TadanoriYamagata UniversityJapanLongitudinal analysis for J-ADNI database by MRI/PET image fusion2017-12-26—2026-03-02
    Mikihiro YasudamissingJapanConstruction of a method for analyzing brain networks based on fMRI data2023-08-25—2025-01-23
    Adams HieabErasmus MCNetherlandsUncovering Neurodegenerative Insights Through Ethnic Diversity2021-04-28—2024-04-12
    Hirakawa AkihiroInstitute of Science TokyoJapanDevelopment and validation of disease progression prediction model in Alzheimer’s disease using cognitive assessment data2020-12-04—2028-03-31
    Masuda HirokiGraduate School of Medicine, Chiba UniversityJapanAnalysis of the longitudinal brain atrophy and cognitive function in patients with multiple sclesosis and neuromyelitis optica spectrum disorder.2021-11-30—2027-03-31
    Ishii KenjiTokyo Metropolitan Geriatric Hospital and Institute of GerontologyJapanAnalysis of J-ADNI PET data using NBDC human database.2016-05-02—2021-03-19
    Suhy JoyceBioclinica, Inc.USAvMRI validation on Toshiba Scanners using J-ADNI data2017-04-04—2019-02-07
    Bock JasonEmbicUSADeveloping Hierarchical Bayesian Cognitive Processing Models for Description, Group Differentiation, and Prediction with Wordlist Memory Test2021-05-25—2025-06-06
    Takahashi KentaroEisai Co., Ltd.JapanComprehensive AD biomaker and disease modifying drug development related analysis by using J-ADNI data2016-09-23—2027-03-31
    Aoshima KenEisai Co., Ltd.JapanComprehensive AD biomaker and disease modifying drug development related analysis by using J-ADNI data2016-09-23—2027-03-31
    Aoyagi KatsumiFUJIREBIO INC.JapanDiagnostic Potential of Dementia Biomarkers in Japanese Clinical Cases.2024-09-03—2025-08-26
    Suzuki KazushiNational Defense Medical CollegeJapanNatural history study of neurodegenerative diseases using clinical research data2017-10-11—2031-03-31
    Sato KenichiroThe University of Tokyo HospitalJapanData analysis research regarding social implementation of novel Alzheimer's disease treatment2025-12-01—2030-03-31
    Kikuchi MasatakaNiigata UniversityJapanImputation analysis using a Japanese reference panel2019-01-21—2025-10-16
    Kasai Kiyotothe University of Tokyo HospitalJapanConstruction of a database comprising brain images acquired with magnetic resonance imaging and clinical evaluation scales and its multi-centered collaborative operation2017-07-19—2021-02-02
    Kowa HisatomoKobe University Graduate School of Health SciencesJapanOptimizing Evaluation Method for Cognitive Function of Aged People Based on the J-ADNI Database2020-01-15—2023-07-10
    Yi FanZhejiang UniversityChinaResearch on the analysis method of chronic disease evolution process based on data mining of electronic medical records2022-11-25—2024-01-01
    Jang Jae-WonKangwon National University HospitalKoreaCOMPREHESIVE VISURAL RATING SCALE ON MRI: APPLICATION TO ALZHEIMER’S DISEASE, MILD COGNITIVE IMPAIRMENT AND SUBJECTIVE MEMORY IMPAIRMENT2017-05-02—2021-01-23
    Ishida ManabuERISA Co., Ltd.JapanDevelopment of diagnosis support program using machine learning for brain MRI2018-01-09—2025-04-10
    Hofmann-Apitius MartinFraunhofer Institute for Algorithms and Scientific Computing SCAIGermanyThe Virtual Brain - Cloud (Personalized Recommendations for Neurodegenerative Disease)2020-03-11—2025-01-22
    Kikuchi MasashiMSD K.K. JapanJapanStudy to investigate disease progression in Japanese mild cognitive impairment and Alzheimer's disease patients2016-10-12—2021-03-18
    Matsuda HiroshiNational Center of Neurology and PsychiatryJapanStudy on neuroimaging using open files from Japanese Alzheimer's disease neuroimaging initiative2016-06-01—2021-03-01
    Donohue MichaelUniversity of Southern CaliforniaUSABuilding predictive algorithms to identify resilience and resistance to Alzheimer’s disease2016-03-30—2021-03-26
    Okochi MasayasuOsaka UniversityJapanUtilization of Data obtained by J-ADNI research for the purpose of development of blood-based Alzheimer's disease biomarker2017-02-02—2021-12-20
    Ekpanyapong MongkolAsian Institute of Technology(AIT)ThailandTechnical, clinical validation and diagnostic accuracy of artificial intelligence (AI) based quantitative structural MRI application for dementia diagnosis in Thai population.2024-01-25—2025-07-31
    Sasaki MasayukiKyushu UniversityJapanStudy of imaging biomarkers for dementia based on the clinical research database2017-06-21—2022-03-03
    Takemura MasahikoOpen Health InitiativeJapanDeveloping and validating models that predict cognitive decline2021-05-14—2023-03-30
    NAKAYA AkihiroOsaka UniversityJapanOmics research for dementia based on clinical and genome data2019-01-21—2022-10-03
    Maserejian NancyBiogenUSANatural history of MCI and AD2018-10-04—2026-12-31
    Tomita NaokiTohoku university hospitalJapanInvestigations on common geriatric problems using international database of Alzheimer's disease2019-06-06—2024-11-12
    Ono TetsutaroDai Nippon Printing Co., Ltd.JapanStudy on morphological change due to aging of the brain and early diagnosis support of Alzheimer type dementia using recorded MR image data.2018-04-20—2027-03-31
    Visser PieterMaastricht UniversityJapanAmyloid Biomarker Study2020-11-09—2024-05-02
    Takahashi RyuichiHyogo Prefectural Rehabilitation Hospital at Nishi-HarimaJapanSearch for ApoE4 effects on amyloid deposition and gray matter atrophy by using of PiB-positive MCI2016-04-27—2018-09-06
    Buckley RachelMassachusetts General HospitalUSABuilding predictive algorithms to identify resilience and resistance to Alzheimer’s disease2024-02-14—2028-02-25
    Shimasaki RyosukeTokyo Metropolitan Institute for Geriatrics and GerontologyJapanCharacteristics of Lecanemab Treatment Candidates Using J-ADNI Data2025-09-18—2027-12-31
    Sakatani KaoruIko Health TechnologiesJapanStudy on the risk prediction of dementia by analyzing the Human Database: J-ADNI2022-02-25—2022-09-01
    Black SandraSunnybrook Research InstituteCanadaComparative study on the longitudinal changes in cerebral small vessel disease between Japanese and Western country populations2022-07-13—2027-05-31
    Senda MichioInstitute of Biomedical Research and InnovationJapanEvaluation of imaging biomarkers for dementia based on the J-ADNI dataset2016-08-05—2021-02-10
    Shiino AkihikoShiga University of Medical ScienceJapanNeuroimage diagnosis of dementia using J-ADNI database2017-06-30—2018-08-08
    Yang PengTakeda Pharmaceutical Company LimitedJapanDevelopment of machine learning prediction model for detecting neurodegenerative diseases using J-ADNI human brain image data2022-09-21—2027-05-31
    Suda AkiraYokohama City University HospitalJapanRetrospective investigation on relationship between immunological biomarkers and clinical findings of Alzheimer's disease2020-01-09—2023-02-06
    Suzuki HiroshiThe University of Tokyo HospitalJapanAn Analysis of The Progression of Alzheimer's Disease in The Japanese Population by Using J-ADNI Data2017-01-11—2025-09-02
    Watanabe SayuriJanssen pharmaceutical K.KJapanAnalysis of J-ADNI data2018-06-07—2028-04-30
    Katabathula SreevaniCase Western Reserve UniversityUSASubtype Analysis in Mild cognitive impairment of Alzheimer’s disease2023-08-09—2024-08-02
    Kato TakashiNational Center for Geriatrics and GerontologyJapanAnalyses of the J-ADNI data2016-10-14—2027-03-31
    Miyashita AkinoriNiigata UniversityJapanStudy on dementia with large-scare omics data2020-06-04—2028-01-23
    FUNANE TSUKASAHitachi, Ltd.JapanResearch on changes in clinical condition and diagnostic marker in Alzheimer's disease (AD) patients, mild cognitive impairment (MCI) patients, and healthy control (HC) people using Alzheimer's disease clinical databases that are collected and opened by domestic and international organizations2017-12-11—2021-01-25
    Suzuki ToshiharuHokkaido UniversityJapanNBDC Human Database use for analysis of p3-Alc peptides, the blood biomarker for Alzheimer's disease2017-05-02—2024-11-15
    WENG TING-WEITaipei Medical UniversityTaiwanBuilding a national model of data hub for healthy aging2022-05-24—2024-06-18
    ABDULLAH SHAHRUM SHAHUnversiti Teknologi MalaysiaMalaysiaDiagnosing Alzheimer’s Disease in a Japanese Population Using Deep Learning Approach2023-12-28—2024-12-13
    Wachinger ChristianTechnical University of MunichGermanyReplication of neural network predictions on independent test data2022-03-28—2026-12-31
    Robieson WeiningAbbVieUSAEvaluation of longitudinal changes in clinical assessments and biomarkers for subjects with mild cognitive impairment (MCI), Alzheimer's Disease (AD) and normalcontrols using Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) data2016-08-05—2022-07-19
    Yamaguchi ShuheiShimane UniversityJapanDevelopment of diagnosis support program using machine learning for brain MRI2018-01-09—2035-03-31
    Yamamoto TosimasaSaitama Medical UniversityJapanEvaluation of a method for objectively evaluating brain image change using brain image analysis software in degenerative diseases including Parkinson's syndrome and Alzheimer type dementia.2017-09-14—2023-06-30
    Li YuanzhongFUJIFILM CorprationJapanAcquisition of data for evaluation of dementia diagnosis2017-09-05—2024-09-06