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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0024-v1Release info

Latest

Research title

Comprehensive Analysis of Genetic Alterations in Hematological Malignancies

Research overview

Aims
To perform a comprehensive analysis of genetic alterations of myelodysplastic syndromes (MDS) and related myeloid neoplasms (myelodysplasia).
Methods
Whole-exome sequencing of gDNAs extracted from leukemic cells and paired non-leukemic cells (Illumina Genome Analyzer IIx, HiSeq 2000, and HiSeq 2500).
Participants/materials
13 MDSs and 1 chronic myelomonocytic leukemia (CMML) (leukemic cells and paired non-leukemic cells)
URL

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000023NGS (Exome)
  • WES
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Seishi Ogawa
Affiliation
Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas
システム的統合理解に基づくがんの先端的診断, 治療, 予防法の開発
  • 22134006
KAKENHI Grant-in-Aid for Scientific Research (A)
Analysis on genetic basis of leukemia relapse and therapy resistance
  • 23249052
KAKENHI Grant-in-Aid for Young Scientists (B)
Exploring new gene target of 4q-UPD in Myelodysplastic syndromes
  • 21790907
New Energy and Industrial Technology Development Organization (NEDO)
機能性アレルのデジタルカウントによる次世代"ExpressGenotype法"とその産業応用
  • 08C46598a
Project for Development of Innovative Research on Cancer Therapeutics (P-DIRECT)
骨髄異形成症候群におけるエピゲノム関連マーカーの探索と実用化
N/A
Health and Labour Science Research Grants from the Japanese Ministry of Health, Labour and Welfare, and Research on Measures for Intractable Disease
不応性貧血の治癒率向上を目指した分子・免疫 病態研究
N/A
Cabinet Office, Government of Japan Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST)
Development of medical technologies for treating intractable cancers and cardiovascular diseases
N/A

Related publications

TitleDOIDataset ID
Frequent pathway mutations of splicing machinery in myelodysplasia.
https://doi.org/10.1038/nature10496 (opens in a new tab)
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
https://doi.org/10.1038/ng.2731 (opens in a new tab)
The landscape of somatic mutations in Down syndrome-related myeloid disorders.
https://doi.org/10.1038/ng.2759 (opens in a new tab)
Landscape of genetic lesions in 944 patients with myelodysplastic syndromes.
https://doi.org/10.1038/leu.2013.336 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.